Effects of Arsenic (+3 Oxidation State) Methyltransferase Gene Polymorphisms and Expression on Bladder Cancer: Evidence from a Systematic Review, Meta-analysis and TCGA Dataset.

Toxicological Sciences : an Official Journal of the Society of Toxicology
Yuxuan SongXiaoqiang Liu

Abstract

Inorganic arsenic (iAs) is a recognized environment-related factor for bladder cancer (BCa). Arsenic (+3 oxidation state) methyltransferase (AS3MT) gene might influence BCa by regulating iAs metabolism. The aim of the present study was to explore whether AS3MT polymorphisms could affect BCa susceptibility. We systematically reviewed eligible case-control studies about AS3MT polymorphisms and BCa and to further compare the genotype distribution and allele distribution between BCa patients and controls by meta-analysis for humans. Besides, to clarify the effects of AS3MT expression on BCa clinical outcomes and survival time, we also conducted a series of analyses based on The Cancer Genome Atlas dataset. Databases were systematically retrieved and we applied Stata software to perform meta-analysis. The registration of this study protocol is at PROSPERO and ID is CRD42019133947. Five articles were recruited and pooled results demonstrated that rs3740393 and rs11191438 polymorphisms were related to BCa risk in overall population (p < .05) in the overall population. In addition, GG and GC genotypes in rs3740393 and GG genotype in rs11191438 might be the susceptibility genotypes for BCa. Results based on 168 BCa samples from TGCA ind...Continue Reading

References

Sep 1, 1986·Controlled Clinical Trials·R DerSimonian, N Laird
Nov 12, 2002·Environmental Health Perspectives·Miroslav StýbloDavid J Thomas
Dec 31, 2002·Toxicology·Marie Vahter
May 28, 2003·Journal of Clinical Epidemiology·John AttiaCatherine D'Este
Dec 4, 2003·American Journal of Epidemiology·Craig SteinmausAllan H Smith
Aug 3, 2004·Cancer Causes & Control : CCC·Margaret R KaragasAlan Schned
Nov 30, 2004·Statistics in Medicine·Ammarin ThakkinstianJohn Attia
Nov 9, 2005·Journal of Epidemiology·Yasuaki HayashinoTsuguya Fukui
Aug 3, 2010·Environmental Health Perspectives·Kenneth P CantorManolis Kogevinas
Jul 7, 2011·International Journal of Molecular Sciences·Tetsuro AgusaHisato Iwata
Jul 13, 2012·Environmental Health : a Global Access Science Source·Silvia LetašiováAlena Bartonová
Nov 6, 2012·Biological & Pharmaceutical Bulletin·Daigo Sumi, Seiichiro Himeno
Jul 31, 2013·JAMA Psychiatry·Karolina A AbergEdwin J van den Oord
Jun 4, 2014·Environmental Health : a Global Access Science Source·Nathalie Saint-JacquesTrevor Jb Dummer
Jun 5, 2015·Statistics in Medicine·Andrea GonnermannArmin Koch
Oct 4, 2015·Nature·Ewan Birney, Nicole Soranzo
Oct 4, 2015·Nature·UNKNOWN 1000 Genomes Project ConsortiumGonçalo R Abecasis
Jul 2, 2016·Journal of the Medical Library Association : JMLA·Wichor M BramerTanja Bekhuis
Jul 3, 2016·European Urology·Sebastien AntoniFreddie Bray
Mar 30, 2017·Circulation. Cardiovascular Genetics·Changwei LiTanika N Kelly
Apr 14, 2017·Nature Reviews. Disease Primers·Oner SanliYair Lotan
Apr 24, 2017·Environmental Research·Brenda Gamboa-LoiraLizbeth López-Carrillo
Sep 9, 2017·Nature Medicine·Anthony Letai
Sep 29, 2017·PloS One·Bendik S WinsvoldUNKNOWN International Headache Genetics Consortium
Apr 19, 2018·Toxicological Sciences : an Official Journal of the Society of Toxicology·Ying-Chin LinYu-Mei Hsueh
Aug 29, 2018·Toxicology and Applied Pharmacology·Jessica De LomaKarin Broberg
Sep 20, 2018·Transplant International : Official Journal of the European Society for Organ Transplantation·Alberto ZanettoMarco Senzolo
Oct 3, 2018·Journal of the Medical Library Association : JMLA·Wichor M Bramer
Jan 25, 2019·The Journal of Urology·Hedyeh EbrahimiSiamak Daneshmand
Mar 15, 2019·Movement Disorders : Official Journal of the Movement Disorder Society·Yu GuoJin-Tai Yu
May 2, 2019·Cancer Management and Research·Yongli YangXuezhong Shi
Nov 26, 2019·Regulatory Toxicology and Pharmacology : RTP·I Palma-LaraA Hernández-Zavala

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