Effects of arsenic (As) exposure on the antioxidant status of gills of the zebrafish Danio rerio (Cyprinidae)

Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP
Juliane Ventura-LimaJosé M Monserrat

Abstract

In fishes, arsenic (As) is absorbed via the gills and is capable of causing disturbance to the antioxidant system. The objective of present study was to evaluate antioxidant responses after As exposure in gills of zebrafish (Danio rerio, Cyprinidae). Fish were exposed for 48 h to three concentration of As, including the highest As concentration allowed by current Brazilian legislation (10 microg As/L). A control group was exposed to tap water (pH 8.0; 26 degrees C; 7.20 mg O(2)/L). As exposure resulted in (1) an increase (p<0.05) of glutathione (GSH) levels after exposure to 10 and 100 microg As/L, (2) an increase of the glutamate cysteine ligase (GCL) activity in the same concentrations (p<0.05), (3) no significant differences in terms of glutathione reductase, glutathione-S-transferase and catalase activities; (4) a significantly lower (p<0.05) oxygen consumption after exposure to 100 microg As/L; (4) no differences in terms of oxygen reactive species generation and lipid peroxidation content (p>0,05). In the gills, only inorganic As was detected. Overall, it can be concluded that As affected the antioxidant responses increasing GCL activity and GSH levels, even at concentration considered safe by Brazilian legislation.

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Citations

Apr 4, 2014·Diseases of Aquatic Organisms·Zeliha Selamoglu TalasIbrahim Orun
Apr 2, 2013·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Alessandra Martins da RochaJosé Maria Monserrat
Mar 20, 2013·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Roberta Oliveira LobatoJuliane Ventura-Lima
Mar 9, 2011·Environmental Science and Pollution Research International·Juliane Ventura-LimaJosé M Monserrat
Jun 7, 2014·Ecotoxicology and Environmental Safety·Shuvasree SarkarShelley Bhattacharya
Mar 16, 2013·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Amod KumarParimal K Khan
Nov 8, 2012·Bulletin of Environmental Contamination and Toxicology·Andrea GaionDavide Sartori
Dec 15, 2015·The Science of the Total Environment·Baigal-Amar TuulaikhuuHelena Guasch
Sep 6, 2012·Ecotoxicology and Environmental Safety·Ryan R OtterS Marshall Adams
Jun 16, 2010·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·E David ThompsonGregory D Mayer
Jun 9, 2009·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Micheli Rosa de CastroDaniela Martí Barros
Mar 14, 2012·Environmental Toxicology and Chemistry·Josencler L R FerreiraJosé M Monserrat
Dec 20, 2014·Environmental Toxicology and Chemistry·Mariana Noelia MardirosianAndrés Venturino
Mar 15, 2015·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Dawoon JungBruce A Stanton
Apr 29, 2014·Aquatic Toxicology·Catherine W McCollumMaria Bondesson
Mar 6, 2019·International Journal of Environmental Research and Public Health·Jia PeiWenhong Fan
Jun 25, 2021·Environmental Science and Pollution Research International·Mikhail V Simokon, Alexey M Trukhin

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