Effects of artichoke leaf extract on acute gastric mucosal injury in rats

Biological & Pharmaceutical Bulletin
Kazuo IshidaMikio Ito

Abstract

The present study was designed to clarify the effects of an ethanol extract of artichoke leaf on acute gastric mucosal injury in rats. Oral administration of artichoke leaf extract dose-dependently prevented absolute ethanol-induced (125-500 mg/kg) or restraint plus water immersion stress-induced gastric mucosal injury (1000-2000 mg/kg). The artichoke leaf extract contains 1% cynaropicrin and 0.8% chlorogenic acid as main components and 70% dextrin as a vehicle. Cynaropicrin at doses of 1/100 of artichoke leaf extract [ethanol-induced mucosal injury: 5 mg/kg, per os (p.o.); stress-induced mucosal injury: 20 mg/kg, p.o.] also prevented gastric mucosal injury in both animal models. However, dextrin and chlorogenic acid at doses contained in the leaf extract were ineffective in both models. When artichoke leaf extract was given orally to normal rats, it (500-2000 mg/kg, p.o.) dose-dependently increased gastric mucus content. In addition, it (125-500 mg/kg, p.o.) dose-dependently prevented the decrease in gastric mucus content by absolute ethanol. When the effects of artichoke leaf extract on basal gastric acid secretion in rats were evaluated, it (500-2000 mg/kg, p.o.) dose-dependently increased the volume of gastric juice in norm...Continue Reading

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Citations

Dec 5, 2013·Chemico-biological Interactions·Wei-Feng LiXiao-Feng Niu
Apr 29, 2014·Plant Science : an International Journal of Experimental Plant Biology·Kaouthar EljounaidiJules Beekwilder
Nov 7, 2012·Naunyn-Schmiedeberg's Archives of Pharmacology·André T ShimoyamaSandra H P Farsky
Apr 12, 2013·Journal of the Science of Food and Agriculture·Mahmoud I NassarAbdel-Razik H Farrag
Oct 21, 2015·Evidence-based Complementary and Alternative Medicine : ECAM·Woo-Young JeonHyekyung Ha
Apr 25, 2013·Journal of Ethnopharmacology·Siddig Ibrahim AbdelwahabOnn Haji Hashim
Nov 3, 2012·Evidence-based Complementary and Alternative Medicine : ECAM·Woo-Young JeonHyeun-Kyoo Shin
Sep 13, 2012·Biochimica Et Biophysica Acta·Vicente SaezPier Giorgio Righetti
Jan 14, 2020·Pakistan Journal of Biological Sciences : PJBS·Olfat M Eldin AwadNourhan M Abd El-Aziz
Dec 23, 2016·Frontiers in Pharmacology·Mahmoud F ElsebaiAtanas G Atanasov

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