PMID: 8773160Jan 1, 1996Paper

Effects of aspirin and ibuprofen on the pharmacokinetics and pharmacodynamics of glyburide in healthy subjects

The Annals of Pharmacotherapy
R T KubackaI Welshman

Abstract

To determine the effects of aspirin and ibuprofen on the pharmacokinetics and pharmacodynamics of glyburide in healthy volunteers. Single-center, randomized, two-way, crossover design following an initial baseline evaluation phase. Outpatient, university-based ambulatory care facility. Sixteen healthy nonsmoking men aged 20-34 years. Three phases consisting of six treatments. Phase 1 began with treatment A, a baseline oral glucose tolerance test (GTT), followed by treatment B, glyburide 5 mg plus a GTT. The other two phases were administered in a crossover design. Phase 2 consisted of the administration of aspirin 975 mg qid for 4 days. On day 3 a GTT was administered (treatment C) and on day 4 glyburide 5 mg plus a GTT was administered (treatment E). Phase 3 consisted of the administration of ibuprofen 600 mg qid for 4 days with a GTT on day 3 (treatment D) and glyburide 5 mg plus a GTT on day 4 (treatment F). Serum glyburide concentrations after each treatment, as well as glucose and insulin, ibuprofen, and salicylate serum concentrations and glyburide free fractions. Aspirin administration resulted in an 85% increase in mean total glyburide oral clearance and a 29% increase in glyburide free fraction. Ibuprofen administratio...Continue Reading

References

Jan 15, 1975·Biochemical Pharmacology·M J Crooks, K F Brown
Jan 1, 1977·Drugs·J M Hansen, L K Christensen
Jun 1, 1992·Diabetes Care·L Groop
Feb 1, 1989·Clinical Pharmacokinetics·J J MacKichan
Jan 1, 1980·Therapeutic Drug Monitoring·M Rowland
Jul 1, 1983·Clinical Pharmacology and Therapeutics·G F LockwoodJ G Wagner
Mar 30, 1959·Annals of the New York Academy of Sciences·J M STOWERSR B HUNTER
Jan 1, 1963·Gerontologia Clinica·W F ANDERSON, J THOMPSON

Citations

Nov 5, 1998·Journal of the American Academy of Nurse Practitioners·R Petrikas, L Schumann
Dec 9, 2004·Pharmacotherapy·Lawrence V Friedrich, Richard Dougherty
Mar 7, 2017·Turkish Journal of Medical Sciences·Zafer GörenMedine Gülçebi Idriz Oğlu
Sep 25, 2014·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Muhammad Amin, Naeti Suksomboon
Jan 18, 2006·European Journal of Clinical Pharmacology·Maria Chiara SilvaniNicola Montanaro
Feb 24, 2009·European Journal of Drug Metabolism and Pharmacokinetics·J N Suresh KumarRamesh Mullangi
Apr 20, 2016·Therapeutic Advances in Endocrinology and Metabolism·Marcus May, Christoph Schindler
Apr 19, 2007·Journal of the National Cancer Institute·Rachel P RiechelmannMonika K Krzyzanowska
Oct 26, 2012·Critical Reviews in Clinical Laboratory Sciences·Matthew D Linden, Huyen A Tran

Related Concepts

Analgesics, Anti-Inflammatory
Zorprin
Blood Glucose
Drug Interactions
Neogluconin
Intravenous Glucose Tolerance Test
Hypoglycemic Effect
Ibuprofen, Copper (2+) Salt
Novolin
Cross-Over Studies

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Lipidomics & Rhinovirus Infection

Lipidomics can be used to examine the lipid species involved with pathogenic conditions, such as viral associated inflammation. Discovered the latest research on Lipidomics & Rhinovirus Infection.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Torsion Dystonia

Torsion dystonia is a movement disorder characterized by loss of control of voluntary movements appearing as sustained muscle contractions and/or abnormal postures. Here is the latest research.

Generating Insulin-Secreting Cells

Reprogramming cells or using induced pluripotent stem cells to generate insulin-secreting cells has significant therapeutic implications for diabetics. Here is the latest research on generation of insulin-secreting cells.

Central Pontine Myelinolysis

Central Pontine Myelinolysis is a neurologic disorder caused most frequently by rapid correction of hyponatremia and is characterized by demyelination that affects the central portion of the base of the pons. Here is the latest research on this disease.

Epigenome Editing

Epigenome editing is the directed modification of epigenetic marks on chromatin at specified loci. This tool has many applications in research as well as in the clinic. Find the latest research on epigenome editing here.