PMID: 8773160Jan 1, 1996Paper

Effects of aspirin and ibuprofen on the pharmacokinetics and pharmacodynamics of glyburide in healthy subjects

The Annals of Pharmacotherapy
R T KubackaI Welshman


To determine the effects of aspirin and ibuprofen on the pharmacokinetics and pharmacodynamics of glyburide in healthy volunteers. Single-center, randomized, two-way, crossover design following an initial baseline evaluation phase. Outpatient, university-based ambulatory care facility. Sixteen healthy nonsmoking men aged 20-34 years. Three phases consisting of six treatments. Phase 1 began with treatment A, a baseline oral glucose tolerance test (GTT), followed by treatment B, glyburide 5 mg plus a GTT. The other two phases were administered in a crossover design. Phase 2 consisted of the administration of aspirin 975 mg qid for 4 days. On day 3 a GTT was administered (treatment C) and on day 4 glyburide 5 mg plus a GTT was administered (treatment E). Phase 3 consisted of the administration of ibuprofen 600 mg qid for 4 days with a GTT on day 3 (treatment D) and glyburide 5 mg plus a GTT on day 4 (treatment F). Serum glyburide concentrations after each treatment, as well as glucose and insulin, ibuprofen, and salicylate serum concentrations and glyburide free fractions. Aspirin administration resulted in an 85% increase in mean total glyburide oral clearance and a 29% increase in glyburide free fraction. Ibuprofen administratio...Continue Reading


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Related Concepts

Analgesics, Anti-Inflammatory
Blood Glucose
Drug Interactions
Intravenous Glucose Tolerance Test
Hypoglycemic Effect
Ibuprofen, Copper (2+) Salt
Cross-Over Studies

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