Effects of astaxanthin on VEGF level and antioxidation in human aqueous humor: difference by sex

Journal of Clinical Biochemistry and Nutrition
Hirotaka HashimotoMakoto Chikuda

Abstract

In our previous report, we showed the effect of astaxanthin intake on VEGF level in the aqueous humor and the relationship between VEGF level and reactive oxygen species-related parameters and other relevant factors. VEGF level is associated with total hydroperoxide level, and a multivariate analysis identified sex as a secondary factor affecting these relationships. Here, we analyzed the effects of astaxanthin on the relationship between VEGF level and reactive oxygen species-related parameters by sex. Patients (16 males and 19 females, aged 71.3 and 70.6, respectively) underwent bilateral cataract surgery on one side before and the other side after astaxanthin treatment (6 mg/day for 2 weeks). Levels of VEGF, hydrogen peroxide, and total hydroperoxide, and O2•- scavenging activity, were measured in the aqueous humor. In females only, VEGF level was negatively correlated with O2•- scavenging activity before the astaxanthin intake (r = -0.6, p<0.01) and positively correlated with total hydroperoxide level before and after the astaxanthin intake (r = 0.7 and 0.8, respectively, p<0.01). In conclusion, astaxanthin appears to affect O2•- scavenging activity in the aqueous humor in females, and is likely to be involved in the contro...Continue Reading

References

Sep 8, 2004·Life Sciences·Kenneth ChiangNalini Santanam
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Oct 6, 2006·The New England Journal of Medicine·Philip J RosenfeldUNKNOWN MARINA Study Group
Oct 6, 2006·The New England Journal of Medicine·David M BrownUNKNOWN ANCHOR Study Group
Apr 4, 2008·Investigative Ophthalmology & Visual Science·Kanako Izumi-NagaiSusumu Ishida
Jul 23, 2013·Journal of Clinical Biochemistry and Nutrition·Hirotaka HashimotoYoshitaka Obara
Aug 9, 2016·Journal of Clinical Biochemistry and Nutrition·Hirotaka HashimotoMakoto Chikuda
Dec 14, 2016·Journal of Cellular and Molecular Medicine·Melissa Christine KanderZhenguo Liu
Jul 29, 2017·Journal of Clinical Biochemistry and Nutrition·Kumi TominagaYuki Adachi
Apr 4, 2018·Journal of Clinical Biochemistry and Nutrition·Masahiro HayashiTakashi Maoka

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Citations

Apr 2, 2020·Journal of Clinical Biochemistry and Nutrition·Masahiro HayashiTakashi Maoka
Feb 5, 2021·Journal of Clinical Biochemistry and Nutrition·Kaoru ManabeMasaki Tanito
Feb 17, 2021·Critical Reviews in Food Science and Nutrition·Osman N KanwuguElena G Kovaleva
Apr 22, 2021·Journal of Clinical Biochemistry and Nutrition·Hirotaka HashimotoMakoto Chikuda
Aug 12, 2021·Journal of Clinical Biochemistry and Nutrition·Yuki KizawaTakahiro Yamada
Sep 29, 2021·Critical Reviews in Food Science and Nutrition·Yunrui CaoJie Xu

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay

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