PMID: 3761562Jun 1, 1986Paper

Effects of astromicin on a host defence mechanism

The Japanese journal of antibiotics
H Yoneyama, R Okachi

Abstract

We investigated the effect of astromicin (ASTM) on a defence mechanism. The existence of ASTM (100 micrograms/ml) did not influence the ability of phagocytizing and killing by the mouse peritoneal exudated polymorphonuclear leukocyte (PMN). We observed no change of either phagocytizing and killing or phagocytizing ability of PMN by a pretreatment with ASTM (100 micrograms/ml). When the luminol-dependent chemiluminescence of PMN was examined, a slight decrease of relative light intensity in the presence of ASTM was observed at a concentration of 100 micrograms/ml or 50 micrograms/ml. There was, however, no change of relative light intensity in the presence of 20 micrograms/ml of ASTM. The chemotaxis of PMN was not influenced in the presence of even 100 micrograms/ml of ASTM. We also examined whether a combination effect existed between ASTM and either fresh human serum or fresh mouse serum in vitro. Considerable combination effects were observed against E. coli, P. aeruginosa, S. marcescens, K. pneumoniae and S. aureus. From these results, we concluded that ASTM did not exert a detrimental effect on examined functions of PMN which is important in the nonspecific host defence mechanism in the early phase of bacterial infections. ...Continue Reading

Related Concepts

Related Feeds

Allergy & Infectious Diseases

Allergies result from the hyperreactivity of the immune system to some environmental substance and can be life-threatening. Infectious diseases are caused by organisms including bacteria, viruses, fungi and parasites. They can be transmitted different ways, such as person-to-person. Here is the latest research on allergy and infectious diseases.

Antimicrobial Resistance (ASM)

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Allergy & Infectious Diseases (ASM)

Allergies result from the hyperreactivity of the immune system to some environmental substance and can be life-threatening. Infectious diseases are caused by organisms including bacteria, viruses, fungi and parasites. They can be transmitted different ways, such as person-to-person. Here is the latest research on allergy and infectious diseases.

Aminoglycosides (ASM)

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Antimicrobial Resistance

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Aminoglycosides

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Related Papers

Zentralblatt Für Bakteriologie : International Journal of Medical Microbiology
S Schubert, U Ullmann
Nihon Ketsueki Gakkai zasshi : journal of Japan Haematological Society
Y MorishitaM Hirano
Kansenshōgaku zasshi. The Journal of the Japanese Association for Infectious Diseases
J KadotaK Hiratani
© 2021 Meta ULC. All rights reserved