PMID: 11325076Apr 28, 2001Paper

Effects of AT1 receptor antagonist on proteoglycan gene expression in hypertensive rats

Hypertension Research : Official Journal of the Japanese Society of Hypertension
H SasamuraT Saruta

Abstract

Proteoglycans are an important component of the extracellular matrix, and are thought to play multiple roles not only in kidney remodeling, but also in regulating glomerular permeability, and in modulating the activity of other cytokines and growth factors. The aim of this study was to examine the gene expressions of proteoglycan core proteins in hypertensive rat kidneys, and their modulation by AT1 receptor antagonist. SHRSP/Izm rats and normotensive control WKY/Izm rats on a normal salt diet were treated with or without the AT1 receptor antagonist candesartan cilexetil (1 mg/kg/day) from 10 weeks to 22 weeks. At the end of the treatment period, renal tissue was excised, and gene expressions of the proteoglycan core proteins versican, perlecan, decorin, and biglycan were examined by Northern blot analysis and RT-PCR. Treatment with candesartan cilexetil caused significant decreases in blood pressure and amelioration of proteinuria and renal histological scores in the SHRSP/Izm rats. Compared to WKY/Izm rats, expression of biglycan mRNA showed a small increase in SHRSP/Izm rats which did not attain statistical significance. On the other hand, treatment with candesartan caused significant reductions in biglycan and decorin mRNA ...Continue Reading

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Citations

Sep 13, 2003·Kidney International·Emi KobayashiTakao Saruta
Aug 8, 2002·Kidney International·Mari KurodaTakao Saruta
Nov 19, 2003·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Nan JiaAkira Kitabatake
Oct 9, 2012·European Journal of Pharmacology·Bhoomika M Patel, Anita A Mehta
Jun 9, 2018·Expert Opinion on Therapeutic Targets·Puneet Agarwal, Renu Agarwal
Jul 28, 2006·American Journal of Physiology. Cell Physiology·Puja K Mehta, Kathy K Griendling
Dec 1, 2001·Journal of the American Society of Nephrology : JASN·Ryoko Shimizu-HirotaTakao Saruta

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