Effects of AT1 receptor block begun late in life on normal cardiac aging in rats

Journal of Cardiovascular Pharmacology
Kurt W SaupeCarl S Apstein

Abstract

The goal of this study was to determine how short-term (12 weeks) angiotensin type I (AT1) block begun late in life affects aspects of myocardial biology and physiologic function altered by normal aging. Exercise capacity, myocardial morphology, histopathology, and coronary vascular function (degree of coronary vasodilation in response to adenosine) were evaluated in 53 Fischer 344 rats. Adult (6 months of age) and old (21 months of age) rats were studied after 12 weeks of either control drinking water, a low dose of candesartan that did not significantly lower blood pressure (1 mg/kg/d), or a high dose of candesartan (10 mg/kg/d). Significant age-associated changes in exercise capacity (38% decrease), coronary dilation in response to adenosine (41% decrease), and histopathology occurred but were not affected by candesartan treatment. Age-associated myocardial hypertrophy occurred as indicated by an increase in heart weight-to-tibia length ratio from 0.27 g/cm +/- 0.01 in the adult controls to 0.34 g/cm +/- 0.02 in the old controls (P < 0.05). This hypertrophy in the aged hearts was significantly attenuated by both low-dose (0.30 g/cm +/- 0.01) and high-dose (0.29 g/cm +/- 0.01) candesartan (P < 0.05). Echocardiographic measure...Continue Reading

References

Jun 14, 1991·Mechanisms of Ageing and Development·R D Buñag, T L Teräväinen
Dec 1, 1986·Journal of the American College of Cardiology·P AnversaG Olivetti
Nov 2, 1995·The American Journal of Cardiology·B SwynghedauwJ M Moalic
Jul 1, 1994·The American Journal of Physiology·R N MichelO H Lowry
Apr 30, 1996·Proceedings of the National Academy of Sciences of the United States of America·Y M LiH Vlassara
Dec 1, 1998·American Journal of Hypertension·L FerderF Inserra
May 19, 2000·Experimental Gerontology·J Marín, M A Rodríguez-Martínez
Feb 24, 2001·American Journal of Physiology. Renal Physiology·M W TaalH S Mackenzie
Apr 12, 2001·American Journal of Physiology. Heart and Circulatory Physiology·A K HinschenJ P Headrick
May 9, 2001·Drugs & Aging·K G Pugh, J Y Wei
Aug 22, 2001·American Journal of Physiology. Heart and Circulatory Physiology·D C WelshK B Margulies
Jan 16, 2002·Heart Failure Reviews·Dalane W Kitzman
Feb 28, 2002·Circulation·Federica del MonteRoger J Hajjar
Apr 10, 2002·Circulation·Thuraia NagehRay J Wainwright

❮ Previous
Next ❯

Citations

Feb 15, 2011·International Journal of Cardiology·Yoshiaki Maruyama

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anthelmintics

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.