PMID: 9533614Apr 9, 1998Paper

Effects of AT1 receptor blockade on blood pressure and the renin-angiotensin system in spontaneously hypertensive rats of the stroke prone strain

Clinical and Experimental Hypertension : CHE
J WagnerD Ganten

Abstract

The aim of the study was to assess the effects of chronic angiotensin I receptor blockade on blood pressure, the renin-angiotensin system in plasma and kidney and the extent of renal damage in spontaneously hypertensive rats of the stroke prone strain (SHRsp). Four months old male SHRsp rats were orally treated with a high (10 mg/kg b.w. per day) or a low dose (1 mg/kg b.w. per day) of the AT1 receptor antagonist Telmisartan and compared to Losartan- (20 mg/kg b.w. per day), Captopril-treated (50 mg/kg b.w. per day) or untreated control groups for 38 days. Despite a similar extent of blood pressure reduction in all groups (except low dose Telmisartan), high dose Telmisartan but not Losartan or Captopril significantly reduced left ventricular weight by 24% compared to controls (p<0.05). Renal damage as assessed by urinary albumin or glomerulosclerosis index was significantly reduced in all treatment groups (p<0.02). Plasma renin concentration was significantly elevated (p<0.02) and plasma angiotensinogen significantly lowered (p<0.05) in all pharmacologically treated group compared to controls. In the kidney, renin-mRNA as well as AT1 receptor gene expression were elevated in all treatment groups, but no significant changes were...Continue Reading

References

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Citations

Aug 7, 1999·The American Journal of Cardiology·A Zanchetti
Oct 14, 2011·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Sayaka NagataKazuo Kitamura
May 3, 2000·Kidney International·M W Taal, B M Brenner
Jul 1, 2004·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·Motohiko ChachinHisashi Satoh
Dec 13, 2005·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Shinji TakaiMizuo Miyazaki
Sep 18, 2001·Drugs·M SharpeK L Goa
Aug 12, 2009·European Journal of Pharmacology·Sameer GoyalDharamvir Singh Arya
Aug 7, 1999·The American Journal of Cardiology·P W de Leeuw
Oct 15, 2005·The Journal of International Medical Research·P Verdecchia
Jun 28, 2008·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Guido GrassiGiuseppe Mancia
Mar 7, 2002·Journal of the Renin-angiotensin-aldosterone System : JRAAS·W WienenC Audeval-Gerard
Aug 18, 2020·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Nora HegazyAhmed Fahmy
Jun 3, 1999·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·K D Schlüter, H M Piper
May 3, 2001·Blood Pressure. Supplement·A H Barnett
Feb 15, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Brice OngaliRéjean Couture

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