PMID: 6862582Jul 1, 1983Paper

Effects of atenolol and hydrochlorothiazide on blood pressure and plasma catecholamines in essential hypertension

Hypertension
M G Myers, J de Champlain

Abstract

The antihypertensive effects of atenolol and hydrochlorothiazide were compared with placebo in a randomized, double-blind crossover study, with the blood pressure responses related to sympathetic nervous system activity. Twelve patients with essential hypertension were given atenolol (100 mg), hydrochlorothiazide (50 mg), and placebo as single daily doses, each for 6 weeks. Mean supine, standing, and post-exercise blood pressures (mm Hg) on atenolol (155/94, 152/95, 177/93, respectively) and hydrochlorothiazide (154/99, 150/103, 172/96) were lower (p less than 0.01) than corresponding placebo values (172/109, 166/113, 204/111) at 6 weeks. The role of the sympathetic nervous system in the antihypertensive actions of atenolol and hydrochlorothiazide was examined. The supine plasma norepinephrine on placebo was used as an index of sympathetic activity to categorize each patient's "adrenergic status." The six "hyperadrenergic" patients with high resting norepinephrine values (mean, 302 pg/ml) exhibited a greater (p = 0.05) decrease in BP (-30/-20 mm Hg) on atenolol compared with the BP fall of -9/-11 mm Hg observed in the lower norepinephrine group (mean, 211 pg/ml). Resting plasma norepinephrine values did not predict the BP fall ...Continue Reading

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Citations

Jan 1, 1986·European Journal of Clinical Pharmacology·R VandongenP Rogers
Aug 20, 2015·Naunyn-Schmiedeberg's Archives of Pharmacology·Federica SereniPaola Bagnoli
Feb 19, 2016·American Journal of Hypertension·Guido Grassi
Nov 12, 2009·Journal of Cardiovascular Pharmacology and Therapeutics·S P BelokaP van de Borne
Nov 1, 1986·Hypertension·S LandahlK Svärdsudd
May 30, 2014·The Cochrane Database of Systematic Reviews·Vijaya M MusiniJames M Wright
Mar 11, 2016·The Cochrane Database of Systematic Reviews·Gavin W K WongJames M Wright

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