Effects of atorvastatin 80 mg daily on indices of matrix remodelling in 'high-risk' patients with ischemic heart disease

International Journal of Cardiology
Angel López-CuencaGregory Y H Lip

Abstract

Recent evidence suggests that higher doses of statins could improve clinical outcomes compared to conventional doses, but whether this benefit is due to "additional" pleiotropic effects is uncertain. We tested the hypothesis that atorvastatin 80 mg/day would have beneficial effects on indices of matrix remodelling (matrix metalloproteinase-1, MMP-1, and its tissue inhibitor, TIMP-1) in high-risk cardiovascular disease. We studied 27 "high-risk" patients (inclusion criteria: severe triple vessel but rejected for by-pass for extensive coronary disease, severe effort angina after coronary artery by-pass and premature coronary disease with > or =3 risk factors) with an abnormal lipid profile despite atorvastatin 40 mg/day, at baseline and at 3 months after increasing the statin dose to 80 mg/day. Baseline results in patients were compared to 22 healthy controls. At baseline, patients had lower levels of MMP-1 compared to controls. When atorvastatin was increased to 80 mg/day, significant reduction in LDL-cholesterol was observed, whereas MMP-1 and TIMP-1 levels were increased. These, despite of atorvastatin 40 mg daily, 'high-risk' patients still demonstrated abnormal extracellular remodelling indices. Doubling the dose of atorvast...Continue Reading

References

Mar 7, 1998·American Heart Journal·A Blum, H Miller
May 23, 2001·JAMA : the Journal of the American Medical Association·UNKNOWN Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults
Apr 5, 2002·The Journal of Clinical Endocrinology and Metabolism·S I McFarlaneJ R Sowers
Mar 29, 2003·Stroke; a Journal of Cerebral Circulation·Francisco MarínGregory Y H Lip
Dec 27, 2005·The American Journal of Cardiology·Francisco MarínMariano Valdés
Aug 7, 2007·Journal of the American College of Cardiology·Valerio ZacàHani N Sabbah
Jan 8, 2008·The American Journal of Cardiology·Dimitrios N TziakasHarissios Boudoulas
Apr 1, 2008·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Pablo F CastroSergio Lavandero
Jul 1, 2008·American Heart Journal·Vanessa RoldánVicente Vicente

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Citations

Oct 11, 2008·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Chengyun LiuXuelin Chen

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