Effects of atorvastatin and pravastatin on glucose tolerance, adipokine levels and inflammatory markers in hypercholesterolaemic patients

Clinical and Experimental Pharmacology & Physiology
Hitoshi AndoAkio Fujimura

Abstract

Several randomized clinical trials have suggested that atorvastatin and pravastatin may differ in terms of their pleiotropic effects. To verify this, we compared the effects of both statins on glucose tolerance, adipokine concentrations and inflammatory markers. A total of 36 hypercholesterolaemic patients without known coronary heart disease (CHD) were enrolled in an open-label, randomized, crossover study. The patients received pravastatin or atorvastatin (10 mg/day) for 4 months and then switched to the other statin for an additional 4 months. At the end of both treatment periods, atorvastatin significantly reduced the concentration of serum lipids (total and low-density lipoprotein-cholesterol and triglycerides) and inflammatory markers (high-sensitivity C-reactive protein and tumour necrosis factor-a) and increased serum adiponectin levels compared with pravastatin treatment. Although these effects would be expected to improve insulin sensitivity, atorvastatin did not affect glucose tolerance, which was assessed by fasting glucose and insulin concentrations, the homeostasis model assessment index and glycosylated haemoglobin (HbA(1c)) levels. Only obese patients showed increased HbA(1c) levels after atorvastatin treatment....Continue Reading

References

May 23, 2001·JAMA : the Journal of the American Medical Association·UNKNOWN Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults
Nov 7, 2002·Circulation Journal : Official Journal of the Japanese Circulation Society·UNKNOWN Examination Committee of Criteria for 'Obesity Disease' in Japan, UNKNOWN Japan Society for the Study of Obesity
Mar 5, 2004·JAMA : the Journal of the American Medical Association·Steven E NissenUNKNOWN REVERSAL Investigators
Mar 10, 2004·The New England Journal of Medicine·Christopher P CannonUNKNOWN Pravastatin or Atorvastatin Evaluation and Infection Therapy-Thrombolysis in Myocardial Infarction 22 Investigators
Aug 13, 2004·The New England Journal of Medicine·Pim van der HarstDirk J van Veldhuisen
Aug 18, 2004·Journal of the American College of Cardiology·Yang YuMasakazu Kohno
Jan 22, 2005·Fundamental & Clinical Pharmacology·Michael Schachter
Jul 1, 2005·Metabolism: Clinical and Experimental·Marie-Hélène Gannagé-YaredGeorges Halaby
Oct 18, 2005·Journal of the American College of Cardiology·Kausik K Ray, Christopher P Cannon
Dec 6, 2005·Journal of the American College of Cardiology·Kwang Kon KohMichael J Quon
Apr 6, 2006·Clinical Endocrinology·Tiziana RontiElmo Mannarino
May 31, 2006·Journal of Atherosclerosis and Thrombosis·Tatsuro TakanoAtsushi Okamura
Jul 13, 2006·Journal of Atherosclerosis and Thrombosis·Jun SasakiSuminori Kono
Sep 26, 2006·Nature Reviews. Immunology·Herbert Tilg, Alexander R Moschen
Aug 19, 2007·The Journal of International Medical Research·K MiyagishimaH Hishida

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Citations

Jun 18, 2009·Circulation Journal : Official Journal of the Japanese Circulation Society·Kenshiro AraoShin-Ichi Momomura
May 4, 2011·World Journal of Diabetes·Desiree WandersRobert L Judd
Mar 13, 2014·Clínica e investigación en arteriosclerosis : publicación oficial de la Sociedad Española de Arteriosclerosis·María Valero-MuñozNatalia de Las Heras
Jan 11, 2011·Diabetes/metabolism Research and Reviews·P MatafomeR Seiça
Dec 7, 2010·Atherosclerosis·Kwang Kon KohMichael J Quon
Aug 23, 2011·Atherosclerosis·Tanica LyngdohPedro Marques-Vidal
Jan 13, 2015·Atherosclerosis. Supplements·Lorenzo Arnaboldi, Alberto Corsini
Jan 10, 2012·Kidney & Blood Pressure Research·Magdalena SzotowskaAndrzej Wiecek
May 8, 2019·Archives of Gynecology and Obstetrics·Kusuma Kumari GarikapatiSai Kiran S S Pindiprolu
Oct 18, 2016·Coronary Artery Disease·Qianqian ChenXia Zhong
Aug 29, 2018·Neural Plasticity·Jenna BloemerVishnu Suppiramaniam
Aug 14, 2020·Physiology·Benjamin F Miller, John P Thyfault

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