Effects of atorvastatin on systemic inflammatory response after coronary bypass surgery

Critical Care Medicine
Massimo ChelloElvio Covino

Abstract

Systemic inflammatory response occurs frequently after coronary artery bypass surgery, and it is strongly correlated with the risk of postoperative morbidity and mortality. Recent studies demonstrate that treatment with statin is associated with a significant and marked decrease in inflammation-associated variables such as the C-reactive protein, cytokines, and adhesion molecules. Therefore, we investigated the effects of preoperative atorvastatin treatment on systemic inflammatory response and perioperative morbidity after cardiopulmonary bypass. Double-blinded, placebo-controlled, randomized study. University hospital. Forty patients were randomized to treatment with atorvastatin (20 mg/day, group A, n=20) or placebo (group B, n=20) 3 wks before surgery. Three-week treatment by atorvastatin 20 mg/day. Postoperative serum levels of both interleukin-6 and interleukin-8 increased significantly over baseline, but the peak levels observed 4 hrs postoperatively were significantly lower in the atorvastatin group. In the same fashion, CD11b expression on neutrophils was significantly lower in the statin group at 4 and 24 hrs postoperatively. Finally, neutrophil-endothelial adhesion was significantly reduced in the statin patients com...Continue Reading

References

Nov 1, 1996·The Annals of Thoracic Surgery·E M BoyleB D Spiess
Feb 1, 1997·Critical Care Medicine·J L Vincent
May 1, 1997·Journal of Cardiothoracic and Vascular Anesthesia·G E HillD F Landers
Jul 22, 1998·Proceedings of the National Academy of Sciences of the United States of America·M EndresJ K Liao
Nov 14, 2000·The American Journal of Cardiology·M I DotaniC M Gibson
Jun 30, 2001·The New England Journal of Medicine·M J Tobin
Sep 15, 2001·Cardiovascular Research·S J Miller
Feb 5, 2002·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·D PaparellaE Young
May 29, 2003·The Journal of Thoracic and Cardiovascular Surgery·Harold L LazarSheilah A Bernard
Sep 17, 2003·Circulation·Scott KinlayUNKNOWN Myocardial Ischemia Reduction with Aggressive Cholesterol Lowering Study Investigators
Sep 9, 2004·Circulation·Takatoshi WakeyamaMasunori Matsuzaki

❮ Previous
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Citations

Sep 25, 2009·Neurocritical Care·Tomoko R SampsonMichael N Diringer
Dec 31, 2008·The Journal of Thoracic and Cardiovascular Surgery·Minoru TabataJames D Rawn
Oct 15, 2008·Nature Clinical Practice. Cardiovascular Medicine·Domenico CorradiOttavio Alfieri
Jul 20, 2011·Nature Reviews. Nephrology·Michael Haase, Anja Haase-Fielitz
Apr 9, 2013·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Elmar W KuhnThorsten Wahlers
Jan 29, 2009·European Heart Journal·Diana KaireviciuteGregory Y H Lip
Jun 20, 2008·Cardiology in Review·Justin M BachmannJoseph E Marine
Apr 27, 2012·Journal of Cardiothoracic Surgery·Jose HinzAron Frederik Popov
Jun 21, 2011·Critical Care : the Official Journal of the Critical Care Forum·Allison SutherlandDeon Venter
Oct 21, 2009·Critical Care : the Official Journal of the Critical Care Forum·Catherine MorganPeter Gill
Jul 14, 2010·Circulation Journal : Official Journal of the Japanese Circulation Society·Takeshi KinoshitaKeiji Matsubayashi
Jun 9, 2010·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Concepción MoroRoberto Matía
Aug 30, 2008·QJM : Monthly Journal of the Association of Physicians·J Sánchez-QuiñonesG Y H Lip
Feb 4, 2010·Immunopharmacology and Immunotoxicology·Azza S Awad, Amany El Sharif
Aug 14, 2009·Expert Opinion on Drug Safety·Alexander Kulik, Marc Ruel
May 24, 2007·Current Medical Research and Opinion·Aarti A PatelCraig I Coleman
Nov 26, 2015·Journal of Cardiothoracic and Vascular Anesthesia·Vladimir V LomivorotovAlexander M Karaskov
Oct 4, 2015·Translational Research : the Journal of Laboratory and Clinical Medicine·Campbell S D Roxburgh, Donald C McMillan
Sep 3, 2013·The Annals of Thoracic Surgery·Elmar W KuhnThorsten Wahlers
Jan 1, 2013·The American Journal of Cardiology·J Bradley LaytonM Alan Brookhart
Jan 17, 2012·Journal of the American College of Surgeons·Primal P SinghAndrew G Hill
May 31, 2011·The Annals of Thoracic Surgery·Elmar W KuhnThorsten Wahlers
Mar 1, 2011·The Annals of Thoracic Surgery·Hisato TakagiTakuya Umemoto
Nov 27, 2010·Journal of Cardiothoracic and Vascular Anesthesia·Susan Garwood
Jul 6, 2010·Journal of Cardiothoracic and Vascular Anesthesia·Frederic T BillingsNancy J Brown
Apr 13, 2010·The Journal of Thoracic and Cardiovascular Surgery·Wendy T ChenCraig I Coleman
Aug 25, 2009·The Journal of Thoracic and Cardiovascular Surgery·Oliver J LiakopoulosThorsten Wahlers
Jun 30, 2009·The Annals of Thoracic Surgery·Amedeo AnselmiMario Gaudino
Apr 21, 2009·Journal of Cardiothoracic and Vascular Anesthesia·John G T Augoustides, Prakash Patel
Oct 23, 2008·The American Journal of Cardiology·Salim S ViraniChristie M Ballantyne
Jan 22, 2009·The Journal of Thoracic and Cardiovascular Surgery·Hisato TakagiTakuya Umemoto

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