Effects of atypical and typical antipsychotic treatments on sexual function in patients with schizophrenia: 12-month results from the Intercontinental Schizophrenia Outpatient Health Outcomes (IC-SOHO) study

European Psychiatry : the Journal of the Association of European Psychiatrists
Martin R DossenbachTamas Treuer

Abstract

Sexual dysfunction in patients with schizophrenia can reduce quality of life and treatment compliance. This report will compare the effects of selected atypical and typical antipsychotics on sexual function in a large, international population of outpatients with schizophrenia who were treated over 1 year. Outpatients with schizophrenia, who initiated or changed antipsychotic treatment, and entered this 3-year, prospective, observational study were classified according to the monotherapy prescribed at baseline: olanzapine (N=2638), risperidone (N=860), quetiapine (N=142) or haloperidol (N=188). Based on patient perception, the odds of experiencing sexual dysfunction during 1 year of therapy was significantly lower for patients treated with olanzapine and quetiapine when compared to patients who received risperidone or haloperidol (all P< or =0.001). Females on olanzapine (14%) or quetiapine (8%) experienced a lower rate of menstrual irregularities, compared to females on risperidone (23%) or haloperidol (29%). Significant discordance was evident between patient reports and psychiatrist perception of sexual dysfunction, with psychiatrists underestimating sexual dysfunction (P< or =0.001). These findings indicate clinically relev...Continue Reading

References

Aug 1, 1982·The Journal of Nervous and Mental Disease·A M GhadirianL Annable
Dec 1, 1984·Archives of Sexual Behavior·S Friedman, G Harrison
Jan 1, 1994·Acta Psychiatrica Scandinavica. Supplementum·W W FleischhackerM Kurz
Feb 6, 1999·Journal of Clinical Psychopharmacology·D L KleinbergM Brecher
Apr 6, 1999·Schizophrenia Research·R A Dickson, W M Glazer
May 22, 2002·The Journal of Clinical Psychiatry·Kwang-Soo KimRuth A Dickson
Jun 29, 2002·Life Sciences·Anna Maria Meaney, Veronica O'Keane
Dec 31, 2002·Psychoneuroendocrinology·A J Cutler
Jan 14, 2003·The Journal of Clinical Psychiatry·Diana O Perkins
Mar 26, 2003·Psychoneuroendocrinology·H KnegteringR J van den Bosch
Apr 25, 2003·European Psychiatry : the Journal of the Association of European Psychiatrists·Michele Raja, Antonella Azzoni
Jan 6, 2005·The International Journal of Neuropsychopharmacology·Martin DossenbachMargaret McBride
Jan 1, 1998·European Psychiatry : the Journal of the Association of European Psychiatrists·J PeuskensM De Hert

❮ Previous
Next ❯

Citations

Dec 21, 2006·Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz·Uwe Hartmann, C Rüffer-Hesse
Jan 4, 2012·The Pharmacogenomics Journal·B AlmogueraUNKNOWN Spanish Consortium of Pharmacogenetics Research in Schizophrenia
Sep 20, 2007·International Journal of Clinical Practice·K Rele, K Wylie
Jan 1, 2011·Schizophrenia Research and Treatment·Ahmed MahmoudShôn W Lewis
Nov 30, 2011·International Journal of Psychiatry in Clinical Practice·Ahmed MahmoudShôn W Lewis
Jun 26, 2007·Current Medical Research and Opinion·Gary SullivanDavid Taylor
Mar 11, 2010·The Journal of Sexual Medicine·Angel L MontejoUNKNOWN Spanish Working Group for the Study of Psychotropic-Related Sexual Dysfunction
Nov 17, 2009·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Xiang Rong ZhangGavin P Reynolds
Jun 3, 2009·Comprehensive Psychiatry·Aytul Gursu HaririAhmet Ertan Tezcan
May 12, 2010·Clinical Endocrinology·Richard I G Holt, Robert C Peveler
Mar 8, 2011·World Psychiatry : Official Journal of the World Psychiatric Association (WPA)·Marc DE HertStefan Leucht
Dec 19, 2011·Journal of Sex & Marital Therapy·Mark E BushongMatthew J Byerly
Dec 22, 2010·Nordic Journal of Psychiatry·Marija Vučić-PeitlEduard Pavlović
Nov 21, 2007·European Psychiatry : the Journal of the Association of European Psychiatrists·Antonio CiudadInmaculada Gilaberte
Aug 16, 2016·The Psychiatric Clinics of North America·Anita H ClaytonJennifer G Votta
Feb 24, 2017·Acta Pharmaceutica : a Quarterly Journal of Croatian Pharmaceutical Society and Slovenian Pharmaceutical Society, Dealing with All Branches of Pharmacy and Allied Sciences·Cvetka Bačar BoleAleš Mrhar
Jan 9, 2017·Journal of Obstetrics and Gynaecology Canada : JOGC = Journal D'obstétrique Et Gynécologie Du Canada : JOGC·John Lamont
Mar 1, 2008·Journal of Psychopharmacology·Amna MirKatherine J Aitchison
Apr 14, 2018·Women's Health·Rosemary Basson, Thea Gilks
Apr 19, 2013·The World Journal of Men's Health·Yeon Won ParkJun Ho Lee
Apr 22, 2011·Journal of Clinical Psychopharmacology·Peter MalikUNKNOWN EUFEST Study Group
Feb 7, 2007·Current Opinion in Psychiatry·Peter Malik
Mar 15, 2008·Human Psychopharmacology·Martin Baggaley
Jan 13, 2009·Acta Psychiatrica Scandinavica. Supplementum·P E BebbingtonM Toumi
Apr 15, 2008·International Clinical Psychopharmacology·Victor PerezUNKNOWN TESIS Study Group
Jul 30, 2010·Clinical Pharmacology and Therapeutics·A Serretti, A Chiesa
Mar 9, 2007·European Psychiatry : the Journal of the Association of European Psychiatrists·Alp UçokSahap Erkoç
May 14, 2020·The International Journal of Neuropsychopharmacology·Rachael W TaylorAnthony J Cleare
Jul 5, 2017·International Urology and Nephrology·Mehmet Hanifi TanyeriBekir Faruk Erden
Dec 18, 2007·Sexual Health·David PlevinPenny Roughan
May 12, 2020·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Casper SchmidtValerie Voon
Nov 13, 2019·Progress in Neuro-psychopharmacology & Biological Psychiatry·Marion DumontaudGuillaume Fond

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here