PMID: 18214125Jan 25, 2008Paper

Effects of atypical pneumonia agents on progression of atherosclerosis and acute coronary syndrome

Acta Cardiologica
Erkan IrizVelit Halit

Abstract

The aim of this study was to investigate the presence of various atypical pneumonia agents (Chlamydia pneumoniae, cytomegalovirus, Mycoplasma pneumoniae), which are considered to have a role in the ethiopathogenesis of atherosclerosis, in aortic biopsies without macroscopically visible plaque and in internal thoracic artery biopsies. Thirty-three patients (group 1), who had undergone coronary bypass operation and 10 non-atherosclerotic patients (group 2), were included in the study. Seventy-six tissue biopsies were taken. Biopsies from the patients in group 1 a were obtained from the atheroma plaque-free aortic tissue and 33 biopsies (group Ib) were obtained from their internal thoracic arteries. Following DNA extraction, nested PCR was used to detect Chlamydia pneumoniae DNA, and real time PCR was used to detect cytomegalovirus and Mycoplasma pneumoniae DNA. Blood parameters (lipid profile, CRP, fibrinogen) of the patients and operation characteristics were recorded. Chlamydia pneumoniae DNA was detected in 5 of 33 biopsy samples from coronary bypass patients, whereas none of the control patients (group 1b and group 2) were positive for this agent (P = 0.001). Neither CMV nor Mycoplasma pneumoniae was detected in IMA and aorti...Continue Reading

Citations

Jul 3, 2010·International Journal of Medical Sciences·Ivan M PetyaevYuriy K Bashmakov
Jan 24, 2015·QJM : Monthly Journal of the Association of Physicians·W-S ChungC-H Kao
Jan 24, 2012·International Journal of Cardiology·Tsan-Hon LiouHui-Wen Lin
Sep 7, 2013·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Allen T GriffinForest W Arnold
Nov 20, 2012·Atherosclerosis·Wen-Rui HaoTsan-Hon Liou
Jul 7, 2017·Respirology : Official Journal of the Asian Pacific Society of Respirology·Sheng-Huei WangChih-Hao Shen

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