Effects of autogenous bone graft impaction and tricalcium phosphate on anterior interbody fusion in the porcine lumbar spine

Acta Orthopaedica Scandinavica
Haisheng LiCody Bünger

Abstract

Background Impaction grafting can be achieved inside the spinal fusion cages, but its effect on bone graft incorporation and spinal fusion has not been studied. Animals and methods We investigated the effect of impaction grafting on the bone graft healing and fusion potential of beta-tricalcium phosphate (beta-TCP) inside the carbon fiber reinforced spinal fusion device (Brantigan cage) in 10 Danish landrace pigs. Lumbar spine interbody fusion of L2/3, L4/5 and L6/7 using carbon fiber cages was performed on each pig. Cages filled with either loosely-packed autologous iliac bone graft, rod-impacted autologous bone graft or beta-TCP were randomly distributed to the three fusion levels. Half of the animals were followed for 8 weeks, and the other half for 16 weeks. Results Radiographs and CT evaluations showed that autograft levels had significantly better results than beta-TCP levels (p<0.001 Fisher's Exact Test). However, the difference between impacted and loosely-packed levels was not significant. Histomorphometric analysis showed no difference between the loosely-packed and impacted cages with regard to bone volume, bone marrow volume, cartilage and fibrous tissue volume, while both of the autograft levels differed from the b...Continue Reading

References

Apr 8, 1998·Spine·B K Weiner, R D Fraser
Jan 5, 2002·Biomaterials·S van der DonkB W Schreurs
Oct 18, 2002·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Haisheng LiCody Bünger

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Citations

Oct 19, 2006·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Margriet G MullenderPaul I J M Wuisman
Jun 21, 2017·Clinical Spine Surgery : a Spine Publication·Yu QianMinghao Zheng
Oct 13, 2006·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·J J C ArtsP Buma

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