Aug 1, 1976

Effects of autonomic drugs on epididymal contractions

Fertility and Sterility
J Hib

Abstract

The spontaneous contractility of rat epididymis was recorded in vivo and the effects of various autonomic drugs were studied. Norepinephrine, epinephrine, and orciprenaline produced a sudden increase in tonus and in the size and frequency of epididymal contractions. Phentolamine (an alpha-blocker agent) inhibited the effects of norepinephrine. On the other hand, alprenolol (a beta-blocker agent) inhibited the effects of orciprenaline but did not block the effects of norepinephrine. In addition, phentolamine and alprenolol decreased the spontaneous activity of the epididymis. Acetylcholine produced effects similar to those of norepinephrine. These effects were blocked by atropine. The results described would indicate the presence of the two receptors, alpha and beta, and that both are mediators of stimulatory effects.

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Mentioned in this Paper

Z-Max
Epididymis
Smooth Muscle
Norepinephrine, (+, -)-Isomer
Medihaler-Epi
Atropen
Neurohormones
Norepinephrine Receptors
Alprenolol Hydrochloride
Acetylcholine Sulfate (1: 1)

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