Effects of AWD 140-190 on stimulus-induced field potentials and on different patterns of epileptiform activity induced by low calcium or low magnesium in rat entorhinal cortex hippocampal slices

Epilepsy Research
V ArmandU Heinemann

Abstract

AWD 140-190 a potent new anticonvulsant was tested on several types of epileptiform activities in entorhinal cortex hippocampal slices. AWD 140-190 suppressed completely and in a dose-dependent manner spontaneous seizure-like events induced by lowering extracellular Ca2+. In the low magnesium model, AWD 140-190 applied with 200 microM reduced recurrent short discharges in area CA1 by 48.1 +/- 14.7%, while in the entorhinal cortex seizure-like events were not depressed. Late recurrent discharges were increased in frequency to 213.8 +/- 78.1 and reduced in amplitude by 50.1 +/- 14.4%. Responses to paired pulse stimuli with intervals ranging from 20 to 150 ms were reduced both with alvear and stratum radiatum stimulation. Decreases in [Ca2+]0 and associated slow field potentials evoked by repetitive stimulation of stratum radiatum were also depressed in a dose-dependent manner. AWD 140-190 also reduced stimulus-induced rises in [K+]0. AWD 140-190 200 microM diminished the amplitude of slow field potentials observed during high K(+)-induced spreading depression by about 17% in CA1 and 34% in entorhinal cortex without any significant effect on SD-associated rises in [K+]0. These results suggest that AWD 140-190 has an anticonvulsant...Continue Reading

References

Sep 1, 1977·Epilepsia·J A Ferrendelli, D A Kinscherf
Oct 1, 1991·Epilepsy Research·U HeinemannC L Zhang
Aug 1, 1986·Annals of Neurology·Y YaariJ H Pincus
Jul 14, 1995·Brain Research. Developmental Brain Research·T GloveliU Heinemann
Jan 1, 1993·Epilepsia·R L Macdonald, K M Kelly
Jan 1, 1996·Epilepsia·N MurakamiA Tanaka
Jul 1, 1997·Epilepsy Research·A RostockH S White

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