Effects of axonal topology on the somatic modulation of synaptic outputs.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Takuya SasakiYuji Ikegaya

Abstract

Depolarization of the neuronal soma augments synaptic output onto postsynaptic neurons via long-range, axonal cable properties. Here, we report that the range of this somatic influence is spatially restricted by not only axonal path length but also a branching-dependent decrease in axon diameter. Cell-attached recordings of action potentials (APs) from multiple axon branches of a rat hippocampal CA3 pyramidal cell revealed that an AP was broadened following a 20 mV depolarization of the soma and reverted to a normal width during propagation down the axon. The narrowing of the AP depended on the distance traveled by the AP and on the number of axon branch points through which the AP passed. These findings were confirmed by optical imaging of AP-induced calcium elevations in presynaptic boutons, suggesting that the somatic membrane potential modifies synaptic outputs near the soma but not long-projection outputs. Consistent with this prediction, whole-cell recordings from synaptically connected neurons revealed that depolarization of presynaptic CA3 pyramidal cells facilitated synaptic transmission to nearby CA3 pyramidal cells, but not to distant pyramidal cells in CA3 or CA1. Therefore, axonal geometry enables the differential ...Continue Reading

Citations

Nov 29, 2012·Nature Reviews. Neuroscience·Dominique DebanneSylvain Rama
Oct 19, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Kerry M BrownGiorgio A Ascoli
Feb 18, 2014·International Archives of Medicine·Julia LedderoseMario Treviño
Dec 3, 2014·Biochimica Et Biophysica Acta·Sylvain RamaDominique Debanne
Mar 13, 2013·The Journal of Physiology·Asif RahmanMarom Bikson
Jan 10, 2013·Neuroscience Research·Takuya Sasaki
Mar 26, 2016·Frontiers in Neuroscience·Marta K LewandowskaAndreas R Hierlemann
Jun 24, 2014·Journal of Neuroscience Methods·Isabel Delgado Ruz, Simon R Schultz
May 26, 2016·Molecular Neurobiology·Loredana GuglielmiArmando Felsani
Mar 24, 2017·Scientific Reports·Sylvain RamaDominique Debanne
May 31, 2018·Journal of Neurophysiology·Alessio P BuccinoGaute T Einevoll
Feb 1, 2018·Médecine sciences : M/S·Ronan ChéreauU Valentin Nägerl
Jun 27, 2012·The Journal of Physiology·Takuya SasakiYuji Ikegaya
Aug 23, 2017·Scientific Reports·Netanel OferGur Yaari
Apr 6, 2019·Nature Communications·Rui LiHong-Wei Dong
Mar 21, 2020·Frontiers in Cellular Neuroscience·Mickaël Zbili, Dominique Debanne
May 21, 2019·Frontiers in Cellular Neuroscience·Mickael Zbili, Dominique Debanne
Jun 5, 2020·Science Advances·Mickaël ZbiliDominique Debanne
Dec 21, 2016·Frontiers in Cellular Neuroscience·Mickael ZbiliDominique Debanne
Nov 21, 2021·Proceedings of the National Academy of Sciences of the United States of America·Mickaël ZbiliDominique Debanne

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.