PMID: 5175Apr 30, 1976

Effects of axotomy on the trans-synaptic regulation of enzyme activity in adult rat superior cervical ganglia

Brain Research
I A Hendry

Abstract

The effects of surgical transection of the postganglionic nerve trunk of the superior cervical ganglion on the total protein content and levels of the enzymes tyrosine hydroxylase, DOPA decarboxylase and choline acetyltransferase have been studied in the adult rat. There is a minor decrease in the total activities of these 3 enzymes accompanied by a large increase in the total protein content of the ganglion. The trans-synaptic induction of the enzyme tyrosine hydroxylase by reserpine is not affected by postganglionic axotomy. Increased activity mediated by reserpine caused no change in the total activities of either DOPA decarboxylase or choline acetyltransferase. Previously observed effects of postganglionic axotomy on preventing transmission through the ganglion are compared with these results and the possible mechanisms by which trans-synaptic induction may occur are discussed.

References

Oct 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·T H JohD Reis
Jan 16, 1974·Life Sciences·H Thoenen
Jan 1, 1970·Proceedings of the National Academy of Sciences of the United States of America·H ThoenenJ Axelrod
Apr 1, 1970·European Journal of Pharmacology·R A MuellerJ Axelrod
Jan 1, 1971·Annual Review of Biochemistry·P B Molinoff, J Axelrod
Apr 18, 1972·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·M R Matthews, G Raisman
Jan 1, 1973·Annual Review of Pharmacology·H Thoenen, J P Tranzer
Apr 28, 1954·The Journal of Physiology·H McLENNAN

Citations

Jan 1, 1983·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·J Leah, C Kidson
Feb 26, 2000·Acta Physiologica Scandinavica·T Flatmark
Aug 1, 1995·Clinical and Experimental Pharmacology & Physiology·I A HendryK Heydon

Related Concepts

Axon
Cell Density
Choline O-Acetyltransferase
DOPA decarboxylase
Potentials, Event-Related
Autonomic Ganglion
Iris (Eye)
Nerve Tissue Proteins
V-Serp
Submandibular Gland

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