PMID: 5175Apr 30, 1976Paper

Effects of axotomy on the trans-synaptic regulation of enzyme activity in adult rat superior cervical ganglia

Brain Research
I A Hendry

Abstract

The effects of surgical transection of the postganglionic nerve trunk of the superior cervical ganglion on the total protein content and levels of the enzymes tyrosine hydroxylase, DOPA decarboxylase and choline acetyltransferase have been studied in the adult rat. There is a minor decrease in the total activities of these 3 enzymes accompanied by a large increase in the total protein content of the ganglion. The trans-synaptic induction of the enzyme tyrosine hydroxylase by reserpine is not affected by postganglionic axotomy. Increased activity mediated by reserpine caused no change in the total activities of either DOPA decarboxylase or choline acetyltransferase. Previously observed effects of postganglionic axotomy on preventing transmission through the ganglion are compared with these results and the possible mechanisms by which trans-synaptic induction may occur are discussed.

References

Jan 1, 1974·Experimental Brain Research·R E Cull
Oct 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·T H JohD Reis
Jan 16, 1974·Life Sciences·H Thoenen
Jan 1, 1970·Proceedings of the National Academy of Sciences of the United States of America·H ThoenenJ Axelrod
Apr 1, 1970·European Journal of Pharmacology·R A MuellerJ Axelrod
Jan 1, 1971·Annual Review of Biochemistry·P B Molinoff, J Axelrod
Apr 18, 1972·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·M R Matthews, G Raisman
May 1, 1974·British Medical Bulletin·W E Watson
Jan 1, 1973·Annual Review of Pharmacology·H Thoenen, J P Tranzer
Jan 1, 1971·International Review of Neurobiology·A R Lieberman
Mar 29, 1954·The Journal of Physiology·G L BROWN, J E PASCOE
Apr 28, 1954·The Journal of Physiology·H McLENNAN

❮ Previous
Next ❯

Citations

Jan 1, 1983·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·J Leah, C Kidson
Feb 26, 2000·Acta Physiologica Scandinavica·T Flatmark
Aug 1, 1995·Clinical and Experimental Pharmacology & Physiology·I A HendryK Heydon

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.