PMID: 3757544Aug 1, 1986Paper

Effects of B-HT 920 in the eye and on regional blood flows in anaesthetized and conscious rabbits

Current Eye Research
L Thörig, A Bill

Abstract

The influence of unilateral ocular instillation of B-HT 920 (50 micrograms) on regional ocular, cerebral and peripheral blood flows was investigated with the labelled microsphere method in conscious and anaesthetized albino rabbits. In urethane-anaesthetized rabbits the intraocular pressure (IOP) fell during 1 hr following topical B-HT 920 whereas no changes in regional blood flows were observed. Only in conscious rabbits was a decrease in regional blood flows found. B-HT 920 caused a short-term reduction in choroidal blood flow by about 20%. Transient vasoconstrictor effects, due to systemic absorption, were also seen in some extraocular tissues. Concomitantly, B-HT 920 reduced the total cerebral blood flow (CBF) by 23%. In the grey matter and hypothalamic region the decrease in flow was about 20%, while in the hippocampal region, thalamic region, collicles and pons-mesencephalon it was about 10%. In experiments with direct blood flow determination from an opened vortex vein, there was no consistent change of uveal vascular resistance, while IOP and mean arterial pressure (MAP) fell dose-dependently following cumulative intravenously administered bolus doses (10 and 50 micrograms/kg) of B-HT 920. Unilateral loss of the mediate...Continue Reading

References

Apr 2, 1979·Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie. Albrecht Von Graefe's Archive for Clinical and Experimental Ophthalmology·H C Innemee, P A van Zwieten
Nov 1, 1975·Experimental Eye Research·A Bill, K Heilmann
Jul 1, 1981·Naunyn-Schmiedeberg's Archives of Pharmacology·H C InnemeeP A van Zwieten
Jan 29, 1982·Documenta Ophthalmologica. Advances in Ophthalmology·H C InnemeeP A van Zwieten
Aug 1, 1984·Acta Physiologica Scandinavica·S F Nilsson, A Bill
Mar 1, 1981·Journal of Autonomic Pharmacology·P B Timmermans, P A van Zwieten
Nov 1, 1982·Naunyn-Schmiedeberg's Archives of Pharmacology·N E AndénU Thornström
Jan 1, 1983·Acta Pharmacologica Et Toxicologica·N E AndénU Thornström

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Citations

Jan 1, 1994·Journal of Ocular Pharmacology·M C Koss, T Gherezghiher
May 11, 2002·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Michael C Koss
Jan 1, 1989·Pharmacology & Therapeutics·M F Sugrue

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