Effects of bacterial lipopolysachharide on peripheral leukocytes in the American alligator (Alligator mississippiensis)

Veterinary Immunology and Immunopathology
Mark MerchantJennifer Bushnell

Abstract

Alligators were injected intraperitoneally with four different doses (10, 1.0, 0.1, and 0.01 mg/kg body weight) of a mixture of bacterial lipopolysaccharides (LPS) derived from three different types of bacteria (Escherichia coli, Pseudomonas aeruginosa, and Klebsiella pneumoniae). Injection of the alligators with the LPS mixture resulted in a dose- and time-dependent increase in total peripheral leukocytes Lymphocytes increased at days 3 and 4 post-injection, and decreased back to baseline levels at day 7 for all doses. Alligators that were not treated, and those injected with pyrogen-free saline, did not exhibit statistically significant changes in total leukocytes during the course of the study. Injection of alligators with 0.5 mg LPS/kg body weight derived from one of three bacterial species revealed that the leukocyte increases observed were not statistically different for all three types of LPS. The animals displayed the same increases in total counts and the levels of all circulating leukocyte types were not different between animals treated with a combination of LPS from all three bacterial species.

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Citations

Jan 30, 2008·BMC Microbiology·Ruisheng AnParwinder S Grewal
Nov 3, 2007·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Mark MerchantKaili Mills
Dec 15, 2015·Chemico-biological Interactions·Pablo A SiroskiMarta D Mudry
Dec 19, 2012·Journal of Immunotoxicology·María Agustina LatorrePablo Ariel Siroski
Jul 5, 2012·Journal of Ethnopharmacology·Sithabile ButheleziKaren du Toit
Aug 1, 2012·Annals of Clinical Microbiology and Antimicrobials·Jintana KommaneeSompong Thammasirirak
Jul 16, 2016·Journal of Immunotoxicology·Siyavash Soltanian
Jun 2, 2007·Journal of Experimental Zoology. Part A, Ecological Genetics and Physiology·Mark MerchantJennifer Berken
Jul 6, 2010·Animal Science Journal = Nihon Chikusan Gakkaihō·Sutthidech PreecharramSompong Thammasirirak
Apr 24, 2020·The Journal of Experimental Biology·Craig M LindTerence M Farrell
Nov 19, 2013·Biology Open·Leandro Nogueira PressinottiJosé Roberto Machado Cunha Da Silva

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