PMID: 9429766Jan 16, 1998Paper

Effects of basal [Ca2+]i on calcium handling in Ca(2+)-overloaded rat cultured heart muscle cells

Cellular Signalling
A Takahashi, T Takamatsu

Abstract

To elucidate the relationship between intracellular free Ca2+ concentration ([Ca2+]i) and Ca(2+)-signalling by the sarcoplasmic reticulum (SR) in Ca(2+)-overloaded heart muscle cells, the direct effects of "basal" [Ca2+]i on calcium waves were investigated by altering the membrane potential. When basal inter-calcium wave (BCW) [Ca2+]i was maintained at a high level, (i) calcium waves showed more gradual and more rapidly suppressed increase in [Ca2+]-profile (P < 0.005), and (ii) calcium waves occurred at a significantly higher frequency and velocity (259% and 137%), than when low BCW [Ca2+]i was maintained. Similar investigations on inhibition of the Na(+)-Ca2+ exchanger, however, showed that membrane potential did not elicit direct effects on calcium waves. These results showed that the elevation of BCW [Ca2+]i per se directly influences Ca(2+)-signalling in heart muscle cells through non-equilibrated release-restoration Ca(2+)-handling by the SR.

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Citations

Sep 20, 2008·Pathology International·Tetsuro Takamatsu
Feb 13, 2001·Biophysical Journal·S SubramanianT F Wiesner
Oct 3, 1999·Physiological Reviews·A TakahashiB Herman

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