Abstract
The JCR:LA-cp rat is obese, insulin resistant, and hyperlipidemic, and the males develop atherosclerosis and ischemic myocardial disease. Benfluorex at 35-40 mg.kg-1 body weight was administered in the food from 10 to 14 weeks of age and resulted in an initial 50% decrease in food consumption. Body weights of male and female rats initially decreased by about 7% and thereafter remained relatively constant, whereas control animals gained about 28% in weight over the treatment period. Pair-fed rats showed body weights virtually identical with those of benfluorex-treated animals. Benfluorex treatment and pair feeding decreased serum triacylglycerol concentrations by about 50%; there was a preferential loss of triacylglycerols containing longer chain fatty acids in the males, whereas this selectivity was not seen in the females. Hyperinsulinemic euglycemic insulin clamp studies were performed using [1-3H]glucose, a tracer that allows for the measurement of total glucose turnover, including hepatic uptake and release. In male cp/cp rats, hyperinsulinemia does not stimulate total glucose turnover, reflecting the very severe insulin resistance, and neither benfluorex treatment nor pair feeding increased total glucose turnover. Hyperins...Continue Reading
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Citations
Aug 8, 1998·European Journal of Pharmacology·J C RussellP J Dolphin
Jul 25, 1997·Atherosclerosis·J C RussellD N Brindley
Jul 25, 1998·Atherosclerosis·M RichardsonJ C Russell
Nov 25, 2000·Journal of Pharmacological and Toxicological Methods·T A Clark, G N Pierce
Jun 25, 1999·Metabolism: Clinical and Experimental·J C RussellP J Dolphin
Aug 14, 2010·JACC. Cardiovascular Imaging·Kejia CaiPatrick M Winter
Apr 17, 2008·American Journal of Physiology. Endocrinology and Metabolism·James C RussellDavid N Brindley
Jul 16, 2014·Scientifica·Patrick M Winter