PMID: 11932001Apr 5, 2002Paper

Effects of benzo[a]pyrene exposure on a fish population resistant to the toxic effects of dioxin-like compounds

Aquatic Toxicology
D NacciElizabeth George

Abstract

Effects of a model polycyclic aromatic hydrocarbon (PAH) were compared in populations of the estuarine fish Fundulus heteroclitus indigenous to a reference site and one highly contaminated with polychlorinated biphenyls (PCBs) and other compounds. The fish population resident to the PCB-contaminated site is genetically resistant to those PCB congeners categorized as dioxin-like compounds (DLCs) that act through the aryl hydrocarbon receptor (AHR). In response to DLC exposures, these DLC-resistant fish showed poor inducibility for enzymes known to be regulated by the AHR pathway and important for the metabolism of xenobiotics including some PAHs that also act as AHR agonists. Therefore, a laboratory study using the model PAH, benzo[a]pyrene (BaP), was conducted to evaluate how PAHs might affect these wild fish populations that differed in their inherent sensitivities to DLCs and in their tissue concentrations of contaminants. Following BaP treatment, the activities of two xenobiotic metabolizing enzymes and the concentrations of BaP-DNA adducts, as measured using the 32P-postlabeling method, were lower in the livers of DLC-resistant than reference fish. These results suggest that DLC-resistance could provide protection following...Continue Reading

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Citations

May 9, 2009·Archives of Environmental Contamination and Toxicology·Hyo-Bang MoonHee-Gu Choi
Nov 18, 2005·Journal of Toxicology and Environmental Health. Part a·Ketil Hylland
Aug 10, 2007·Journal of Toxicology and Environmental Health. Part a·Lee A FrederickCharles D Rice
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Oct 21, 2006·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Mehboob AliSheikh Raisuddin
Feb 25, 2015·The Science of the Total Environment·M RipszamP Haglund
Dec 2, 2014·Mutation Research. Genetic Toxicology and Environmental Mutagenesis·M O ObiakorC D Ezeonyejiaku
May 29, 2016·Environmental Science and Pollution Research International·Machi KawanoAnne McElroy
Aug 16, 2008·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Qiang WanJehee Lee
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Oct 29, 2021·The Science of the Total Environment·Abigail DeBofskyJohn P Giesy

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