PMID: 2118268Jan 1, 1990Paper

Effects of benzodiazepine agonist, inverse agonist and antagonist drugs in the mouse staircase test

Psychopharmacology
D E Emmanouil, R M Quock

Abstract

This study examined the effects of the benzodiazepine agonist midazolam and inverse agonist noreleagnine independently and in conjunction with the antagonist flumazenil in the mouse staircase test. According to this paradigm, the numbers of steps ascended (NSA) and rears (NR) reflect locomotor activity and anxiety, respectively. Midazolam reduced NR at doses that did not affect NSA; this NR-lowering effect was blocked by flumazenil. Noreleagnine increased NR at doses that did not affect NSA; this NR-elevating effect was also blocked by flumazenil. Effective antagonist doses of flumazenil alone had no effect on NR or NSA. The exactly opposite effects of midazolam and noreleagnine on NR and their antagonism by flumazenil are consistent with the postulated activities of these drugs at benzodiazepine receptors.

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Citations

Aug 1, 1992·Pharmacology, Biochemistry, and Behavior·T J HillR L Commissaris
Sep 1, 1992·Pharmacology, Biochemistry, and Behavior·M Freire-GarabalM J Núñez
Nov 1, 1993·Pharmacology, Biochemistry, and Behavior·M Freire-GarabalA Belmonte
Apr 1, 1994·Pharmacology, Biochemistry, and Behavior·R M QuockJ H Merritt
Apr 28, 2001·Pharmacology, Biochemistry, and Behavior·R WeizmanC G Pick
May 29, 2002·Archives of Medical Research·Paavo Pokk, Marika Väli
Mar 8, 2000·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·W B Smith
Aug 26, 2014·BMC Complementary and Alternative Medicine·Miraf MesfinWorkineh Shibeshi
Mar 14, 2007·Anesthesia Progress·Dimitris E Emmanouil, Raymond M Quock
Mar 1, 2003·Experimental Brain Research·Weihong PanChaim G Pick
Jun 1, 2007·Journal of Pharmacological Sciences·Yukio AgoToshio Matsuda
Oct 27, 2020·Naunyn-Schmiedeberg's Archives of Pharmacology·Selda ÖzakmanNurhan Enginar

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