Jan 1, 1975

Effects of benzodiazepines on the binding of tryptophan in serum. Consequences on 5-hydroxyindoles concentrations in the rat brain

Psychopharmacology Communications
S BourgoinM Hanson

Abstract

Benzodiazepines (diazepam, oxazepam, chlordiazepoxide) inhibited competitively the binding of tryptophan onto rat serum albumin. As a result, in vivo treatment with one of these compounds (chlordiazepoxide for instance) induced a significant increase in the concentration of free tryptophan in serum. These observations suggest that the high levels of both 5-hydroxyindoles and tryptophan which occurred in the rat brain after any benzodiazepine administration could be at least partly the consequence of its effect on tryptophan binding in blood.

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Mentioned in this Paper

Anti-Anxiety Effect
Plasma Protein Binding Capacity
PMS-Tryptophan
Brain Chemistry
Alb
Plasma Albumin
Indoles
Tazepam
Hydroxyindoleacetic Acid
Valium

About this Paper

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