Effects of berberine against radiation-induced intestinal injury in mice

International Journal of Radiation Oncology, Biology, Physics
Guang-Hui LiDong-Lin Wang

Abstract

Radiation-induced intestinal injury is a significant clinical problem in patients undergoing abdominal radiotherapy (RT). Berberine has been used as an antimicrobial, anti-inflammatory, and antimotility agent. The present study investigated the protective effect of berberine against radiation-induced intestinal injury. The mice were administrated berberine or distilled water. A total of 144 mice underwent 0, 3, 6, 12, or 16 Gy single session whole-abdominal RT and 16 mice underwent 3 Gy/fraction/d for four fractions of fractionated abdominal RT. Tumor necrosis factor-alpha, interleukin-10, diamine oxidase, intestinal fatty acid-binding protein, malonaldehyde, and apoptosis were assayed in the mice after RT. The body weight and food intake of the mice receiving fractionated RT were recorded. Another 72 mice who had undergone 12, 16, or 20 Gy abdominal RT were monitored for mortality every 12 h. The body weight and food intake of the mice administered with distilled water decreased significantly compared with before RT. After the same dose of abdominal RT, tumor necrosis factor-alpha, diamine oxidase, intestinal fatty acid-binding protein in plasma and malonaldehyde and apoptosis of the intestine were significantly greater in the...Continue Reading

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Citations

Jun 26, 2020·Veterinary Medicine and Science·Xiaofan XuLibao Ma
Aug 17, 2012·International Journal of Molecular Medicine·Jing WangQifeng Yang
Apr 27, 2020·Frontiers of Medicine·Danyang SongDaiming Fan
Nov 14, 2020·Clinical Science·Alexa N CarreraBeshay N Zordoky

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