PMID: 8600349Feb 1, 1996Paper

Effects of beta- and gamma-carboline derivatives of DNA topoisomerase activities

Mutation Research
Y FunayamaN Saijo

Abstract

beta-Carbolines, harman (1-methyl-9H-pyrido[3,4-b]indole) and norharman (9H-pyrido[3,4-b]indole) and gamma-carbolines, 3-amino-1,4-dimethyl-5H-pyrido[4,3-b]indole (Trp-P-1) and 3-amino-4-methyl-5H-pyrido[4,3-b]indole (Trp-P-2), are present in cooked foods and cigarette smoke. We studied the effects of these heterocyclic amines on the activity of DNA topoisomerases. Trp-P-1 and Trp-P-2 inhibited topoisomerase I (topo I) activity with ED50 values of 1.48 and 1.55 micrograms/ml, respectively, in a relaxation assay. Harman and norharman inhibited topo I activity but with much higher ED50 values, 23.8 and 34.4 micrograms/ml, respectively. Trp-P-1 and Trp-P-2 also inhibited topoisomerase II (topo II) activity at about 50 micrograms/ml, in a decatenation assay. Harman and norharman showed a much lower inhibitory effect on topo II activity. None of these compounds stabilized the cleavable complex mediated by topo II. Trp-P-1 and Trp-P-2 intercalated into DNA at concentrations inhibitory to topoisomerases. We considered that the intercalation with DNA and the inhibition of DNA topoisomerases by heterocyclic amines might be partly related to their inhibition of DNA excision repair and their enhancing effect on UV- or chemically induced m...Continue Reading

References

Nov 1, 1977·Nucleic Acids Research·K HayashiT Sugimura
Jan 1, 1989·Annual Review of Biochemistry·L F Liu
Jan 1, 1985·Annual Review of Biochemistry·J C Wang
May 11, 1988·Nucleic Acids Research·A MontecuccoG Ciarrocchi
Jan 1, 1994·Environmental and Molecular Mutagenesis·L R Ferguson, B C Baguley
Nov 16, 1994·Journal of the National Cancer Institute·J A RossL L Robison
Jan 15, 1963·Proceedings of the National Academy of Sciences of the United States of America·L S LERMAN

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Citations

Jul 20, 2000·Archives of Biochemistry and Biophysics·W A PrützH Rüegger
May 24, 2001·Archives of Biochemistry and Biophysics·W A PrützW H Koppenol
Sep 15, 2001·Archives of Biochemistry and Biophysics·W A PrützW H Koppenol
Mar 30, 2004·Biochemical and Biophysical Research Communications·Yongcheng SongRobert Z Qi
Feb 11, 2014·Bioorganic & Medicinal Chemistry Letters·Patrícia de Oliveira FigueiredoWalmir Silva Garcez
Feb 26, 2013·European Journal of Medicinal Chemistry·Hala Bakr El-Nassan
May 22, 2013·European Journal of Medicinal Chemistry·Guoxian ZhangZhenghua Ren
Feb 15, 2002·Bioorganic & Medicinal Chemistry Letters·Kazunobu ToshimaShuichi Matsumura
Mar 23, 2002·Bioorganic & Medicinal Chemistry Letters·Yongcheng SongMui Mui Sim
Dec 28, 1999·Bioorganic & Medicinal Chemistry Letters·J IshidaK H Lee
Jan 22, 2013·Journal of Natural Products·Robert J R JaegerPeter Spiteller
Nov 13, 2008·Cytotechnology·R E Parchment, A Pessina
Aug 25, 2010·DNA and Cell Biology·Shohreh NafisiMohammad Ali Khalilzadeh
Aug 21, 2012·Nucleic Acids Research·Yoshiaki Onishi, Yasuhiro Kawano
May 23, 2012·Antimicrobial Agents and Chemotherapy·Dea ShahinasDylan R Pillai
Feb 11, 1999·Bioscience, Biotechnology, and Biochemistry·H AshidaG Danno
Aug 13, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Zhibin LiQunfang Weng
Jan 3, 2013·European Journal of Medicinal Chemistry·Buxi ShiHuacan Song
Aug 25, 2010·Toxicology and Applied Pharmacology·Mohamed A M El Gendy, Ayman O S El-Kadi
Aug 28, 2016·Bioorganic & Medicinal Chemistry Letters·Jennifer M GiuliettiSeann P Mulcahy
Oct 27, 2015·Organic Letters·Jonathan G VarelasSeann P Mulcahy
Jun 15, 2010·Journal of Photochemistry and Photobiology. B, Biology·Shohreh NafisiFirouzeh Manouchehri
Nov 18, 2005·Biochemical and Biophysical Research Communications·Rihui CaoAnlong Xu
Oct 28, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Bruno PaganoConcetta Giancola
Dec 21, 2004·International Journal of Cancer. Journal International Du Cancer·Qi ChenAnlong Xu
Jun 10, 2011·Expert Review of Neurotherapeutics·Witold PolanskiGabriele Gille
Aug 2, 2011·Dalton Transactions : an International Journal of Inorganic Chemistry·Caiping TanAnlong Xu
Dec 16, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Marina PorchiaCarlo Santini
Mar 5, 2018·Biochemical and Biophysical Research Communications·Xinran GengJinshan Tang
Mar 9, 2021·European Journal of Medicinal Chemistry·Shams AaghazAhmed Kamal
Mar 17, 2018·Bioorganic & Medicinal Chemistry Letters·Hong JiangZhi-Yun Du
Mar 22, 2021·Bioorganic & Medicinal Chemistry Letters·Xu HuHuiming Hua

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