Effects of beta-adrenergic stimulating and blocking agents on the adrenaline response and adenyl cyclase activity of leukocyte in monkey and human being

The Tohoku Journal of Experimental Medicine
S MueT Takishima

Abstract

Using the method in which leukocyte suspensions were incubated with NaF or metaproterenol at 30 degrees C for 15-30 min to allow them to convert 3H-ATP (10 muCi) to 3H-cyclic AMP, followed by separation of the formed 3H-cyclic AMP by common chromatography, the leukocyte adenyl cyclase activity of monkeys and human beings was measured with high reproducibility. The oral administration of metaproterenol increased the leukocyte adenyl cyclase activity which was stimulated by NaF and decreased the count of peripheral eosinophils in some of the monkeys. In the beta-adrenergic blockade of the monkey which was made by administration of propranolol, the leukocyte adenyl cyclase activity significantly decreased. The leukocyte adenyl cyclase from patients with coronary heart disease also decreased after oral medication with propranolol.

Citations

May 1, 1980·The Journal of Allergy and Clinical Immunology·S MueT Takishima

Related Concepts

Adenylate Cyclase
Adrenergic beta-Agonists
Adrenergic beta-Antagonists
Metazoa
Anthropoidea
Blood Glucose
Coronary Heart Disease
Eosinophil
Epinephrine Acetate
Pulse Rate

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