Effects of beta-adrenoceptor agonists and antagonists on thyroid hormone secretion

European Journal of Pharmacology
B Ahrén, C Rerup

Abstract

The effects of various beta-adrenoceptor agents on radioiodine release from the thyroid were studied in mice pretreated with 125I and thyroxine. The non-selective beta-adrenoceptor agonist isopropylnoradrenaline and the selective beta 2-adrenoceptor agonist terbutaline both, and with the same efficacy, enhanced radioiodine release, whereas the selective beta 1-adrenoceptor agonist prenalterol had no such effect. The non-selective beta-adrenoceptor antagonist L-propranolol and the selective beta 2-adrenoceptor antagonist ICI 118,551 both abolished the radioiodine release induced by isopropylnoradrenaline or by terbutaline. The selective beta 1-adrenoceptor antagonist metoprolol inhibited the radioiodine response to isopropylnoradrenaline, but not that to terbutaline. Neither of the beta-adrenoceptor antagonists influenced the radioiodine release induced by TSH. It is concluded that the beta-adrenoceptors involved in the regulation of thyroid hormone secretion are mainly of the beta 2-subtype, and, further, that beta-adrenoceptor agonists and TSH exert their thyroid hormone secretory effects through different mechanisms.

References

Nov 10, 1977·Naunyn-Schmiedeberg's Archives of Pharmacology·E CarlssonB Tångstrand
Jun 1, 1979·Pharmacological Research Communications·C OminiL Puglisi
Jul 1, 1979·Endocrinology·A Melander, F Sundler
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Oct 1, 1965·Acta Endocrinologica·C Rerup, A Melander
Sep 1, 1958·Endocrinology·J M McKENZIE

Related Concepts

Adrenergic beta-Agonists
Metazoa
Iodine Radioisotopes
Mice, Inbred Strains
Norepinephrine Receptors
Beta-adrenergic receptor
Terbutalin von ct
Thyroid Hormones
Thyrotropin
Mouse, Swiss

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