Abstract
The influence of celiprolol (beta1- and beta2-adrenoceptor partial agonist), propranolol (beta1- and beta2-adrenoceptor antagonist), and atenolol (beta1-adrenoceptor antagonist) on heart-rate variability (HRV) was assessed from Holter records in 12 normal volunteers. A combination of summary statistics and nonlinear procedures was used to assess HRV and autonomic balance. Under double-blind and randomised conditions (Latin-square design), subjects received placebo, celiprolol (200 and 800 mg), propranolol (160 mg), atenolol (50 mg), and combinations of these agents. Single oral doses of medication (at weekly intervals) were administered at 22:30 h with sleeping heart rates (HRs) recorded overnight. Compared with placebo, celiprolol (200 and 800 mg) increased the sleeping HR, the HR effect of celiprolol was different from the bradycardia after propranolol, 160 mg, and atenolol, 50 mg. Dose-response effects on HR with celiprolol were evident in the presence of atenolol, unlike those with propranolol that abolished the HR increase between celiprolol, 200 mg and 800 mg. These data were consistent with beta1-selective adrenoceptor agonism with 200 mg but agonism at both the beta1- and beta2-adrenoceptor with celiprolol, 800 mg. The ...Continue Reading
References
Oct 1, 1992·British Journal of Clinical Pharmacology·N M WheeldonB J Lipworth
Jun 1, 1992·Pediatric Research·V L SchechtmanR M Harper
Feb 1, 1991·British Journal of Clinical Pharmacology·B J LipworthD G McDevitt
Jan 11, 1992·Circulation·J T BiggerJ N Rottman
Dec 1, 1991·Sleep·S L RaetzR M Harper
Mar 1, 1991·Journal of the American College of Cardiology·G ZuanettiD J Ewing
Feb 11, 1991·Journal of the American College of Cardiology·J R CookL M Rolnitzky
Jul 1, 1989·British Journal of Clinical Pharmacology·B J LipworthD G McDevitt
Jan 1, 1989·European Journal of Clinical Pharmacology·B J LipworthD G McDevitt
Nov 1, 1987·British Journal of Clinical Pharmacology·P M McCaffreyR G Shanks
Apr 30, 1988·British Medical Journal·D G Altman, M J Gardner
May 1, 1986·Cardiovascular Research·L StangelandJ Lekven
Feb 1, 1987·The American Journal of Cardiology·R E KleigerA J Moss
Jul 10, 1981·Science·S AkselrodR J Cohen
Oct 1, 1984·British Heart Journal·D J EwingP Travis
Oct 1, 1980·British Journal of Clinical Pharmacology·I Oswald
Apr 2, 1981·The New England Journal of Medicine·UNKNOWN Norwegian Multicenter Study Group
Oct 15, 1995·The American Journal of Cardiology·J BrouwerK I Lie
May 1, 1994·Journal of the American College of Cardiology·M J NiemeläH V Huikuri
Apr 1, 1993·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·J P SpiersD W Harron
Jan 1, 1993·Journal of Electrocardiology·M BergovecL Barić
Jun 1, 1993·The American Journal of Cardiology·H MølgaardM Møller
Mar 15, 1996·The American Journal of Cardiology·F PoussetJ Y Le Heuzey
Mar 1, 1996·Pacing and Clinical Electrophysiology : PACE·X CopieL Guize
Jan 1, 1997·British Journal of Clinical Pharmacology·B J Lipworth, A Grove
Apr 1, 1997·British Journal of Clinical Pharmacology·T JarttiI Välimäki
Citations
Dec 16, 1998·Clinical Cardiology·M R BristowE J Eichhorn
Apr 18, 2013·British Journal of Anaesthesia·E BoselliB Allaouchiche
Dec 11, 2013·British Journal of Anaesthesia·E BoselliB Allaouchiche
Jun 10, 2017·Anesthesia and Analgesia·Henry D UptonJamie W Sleigh
Dec 31, 2002·Journal of Psychopharmacology·B SilkeD J King
Jun 15, 1999·Journal of Cardiovascular Pharmacology·B SilkeJ G Riddell
Jul 6, 2019·Minerva anestesiologica·Vlasta DostalovaPavel Dostal
Apr 6, 1999·British Journal of Clinical Pharmacology·C G HanrattyJ G Riddell