PMID: 34976Apr 1, 1979

Effects of beta-adrenoceptor agonists on airway smooth muscle and on slow-contracting skeletal muscle: in vitro and in vivo results compared

Acta Pharmacologica Et Toxicologica
O A OlssonB Waldeck

Abstract

Ten beta-adrenoceptor agonists were examined with respect to a) relaxation of pilocarpine-contracted trachea and depression of contractions of the soleus muscle of the guinea-pig in vitro and b) counteraction of histamine-induced bronchospasm and depression of contractions of the soleus muscle of the cat in vivo. There was a close correlation between the results obtained in vitro and results obtained on the corresponding tissues in vivo in spite of the different species used. A close correlation was also observed between effects on airway smooth muscle and on the soleus muscle contractions in vitro as well as in vivo for all compounds examined.

References

Sep 1, 1977·The Journal of Pharmacy and Pharmacology·B Waldeck
Jul 1, 1977·Clinical and Experimental Pharmacology & Physiology·K Bohmer, C Raper
Jun 1, 1965·The Journal of Pharmacy and Pharmacology·J W CONSTANTINE

Citations

Feb 1, 1986·Acta Pharmacologica Et Toxicologica·A B JeppssonE Widmark
Jan 1, 1990·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·R C Ahrens
Oct 1, 1982·Acta Pharmacologica Et Toxicologica·P AnderssonB Waldeck
Dec 1, 1980·The Journal of Urology·S VaidyanathanR Palaniswamy
Feb 20, 1992·The New England Journal of Medicine·W O SpitzerA S Rebuck

Related Concepts

Adrenergic beta-Agonists
Lobar Bronchus Structure
Felis catus
Cavia porcellus
Ceplene
Inotropism
Smooth Muscle
Salagen
Trachea

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