PMID: 38944Sep 1, 1979

Effects of beta-adrenoreceptor antagonists on sino-aortic baroreflex sensitivity and blood pressure in hypertensive man

Clinical Science
R D WatsonW A Littler


1. Sensitivity of the sino-aortic baroreflex was investigated before and after acute (23 patients) and chronic (23 patients) beta-adrenoreceptor antagonism in patients with essential hypertension. 2. Sensitivity was inversely related to age (r = -0.60) and systolic blood pressure (r = -0.46); a positive relationship was noted between sensitivity and initial pulse intervals (r = 0.40). 3. Sensitivity increased significantly in patients less than 40 years of age after chronic treatment. No change occurred after acute treatment or in older patients treated chronically. 4. The fall in ambulatory intra-arterial blood pressure after chronic treatment was unrelated to alteration of baroreflex sensitivity.


Jan 1, 1981·Medicinal Research Reviews·L Patel, P Turner
Apr 1, 1988·Clinical and Experimental Pharmacology & Physiology·S A Smith, W A Littler
Jan 1, 1985·Clinical and Experimental Hypertension. Part A, Theory and Practice·M A van BaakJ F Smits
Sep 23, 1997·Journal of Cardiovascular Pharmacology·M C JacobsT Thien
Nov 12, 2009·Journal of Cardiovascular Pharmacology and Therapeutics·S P BelokaP van de Borne
Aug 1, 1980·British Journal of Clinical Pharmacology·P Turner
Jan 1, 1987·Fundamental & Clinical Pharmacology·A Berdeaux, J F Giudicelli
Jan 1, 1990·Clinical and Experimental Pharmacology & Physiology·R B MinsonJ P Chalmers

Related Concepts

Adrenergic beta-Agonists
Diastolic Blood Pressure
Pulse Rate
Hypertensive Disease
Sinoatrial Node

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