Jan 1, 1976

Effects of beta-adrenoreceptor blocking drugs on plasma volume. Renin and aldosterone as components of their antihypertensive action

R D Gordon


In young males with essential hypertension, propranolol and pindolol in small doses caused significant expansion of plasma volume (PV) after one month which did not prevent a reduction in BP. With higher doses, changes in PV were inconsistent and reductions in plasma renin activity (PRA) and 24-hour aldosterone excretion (AE) not closely related to BP changes. The effects of beta-adrenoreceptor blocking drugs on PV, PRA, and AE do not appear to be important components of their anti-hypertensive action.

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Mentioned in this Paper

Aldosterone, (+-)-Isomer
Essential Hypertension
Hypertensive Disease
Antihypertensive Agents
Clinical Trials
Aldosterone, (11 beta,17 alpha)-Isomer
Blood Plasma Volume
Adrenergic beta-Antagonists

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