PMID: 9547000Apr 18, 1998Paper

Effects of beta-amyloid peptides on the fluidity of membranes from frontal and parietal lobes of human brain. High potencies of A beta 1-42 and A beta 1-43

Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis
W E MüllerW F Gattaz

Abstract

beta-amyloid peptide (A beta) and several A beta-fragments decrease the fluidity of human cortex membranes in a concentration dependent fashion. The effect of A beta on membrane fluidity increases with peptide length, is most pronounced for A beta 1-43 and can be seen at concentrations as low as 100 nmol/l. While the fragment A beta 25-35 is active, scrambled peptide (A beta 35-25) when investigated under similar conditions shows no effects on membrane fluidity. The effect of A beta peptides on fluidity of the phospholipid bilayer is more pronounced in the hydrocarbon core (labeled with the fluorescence probe 1,6-diphenylhexa-1,3,5-triene) than in the region of the hydrophilic heads (labeled with the fluorescence probe 1-[4'-(trimethylamino)phenyl]-6-phenylhexa-1,3,5-triene). It is suggested that the effect of A beta on neuronal membranes is probably a major initial mechanism in a cascade of events finally leading to neurotoxicity and cell death in Alzheimer's disease.

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Citations

Nov 12, 2002·Chemistry and Physics of Lipids·Marie Paule Mingeot-LeclercqRobert Brasseur
Aug 14, 2003·Journal of Biochemical and Biophysical Methods·John J Kremer, Regina M Murphy
Mar 27, 2003·Neuroscience Research·Motoaki NakamuraHiroyuki Shimizu
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May 1, 2009·Expert Review of Neurotherapeutics·Masahiro KawaharaYutaka Sadakane
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Jun 2, 2012·Journal of Photochemistry and Photobiology. B, Biology·Valeriya M Trusova, Galyna P Gorbenko
Mar 13, 2012·Chemistry and Physics of Lipids·Anna KastornaPaavo Kinnunen
Nov 24, 2007·Biotechnology Journal·Steven S-S WangHwai-Shen Liu
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Jan 1, 2003·Biochimica Et Biophysica Acta·Marie-Paule Mingeot-LeclercqRobert Brasseur
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Nov 28, 2017·Neuroscience Bulletin·Qiujian Yu, Chunjiu Zhong
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Mar 22, 2003·Biochimica Et Biophysica Acta·W Gibson WoodWalter E Müller
Aug 3, 2000·Archives of Pathology & Laboratory Medicine·F A GrecoA K Solomon

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