Effects of beta-carotene and other factors on outcome of cervical dysplasia and human papillomavirus infection

Gynecologic Oncology
S L RomneyRobert D Burk

Abstract

Women with histopathologically confirmed cervical intraepithelial neoplasia (CIN) were followed at 3-month intervals in a randomized double-blinded trial to evaluate the efficacy of beta-carotene to cause regression of CIN. Questionnaire data, plasma levels of micronutrients, and a cervicovaginal lavage for human papillomavirus (HPV) detection were obtained at each visit, and an endpoint biopsy was performed at 9 months. Sixty-nine subjects had a biopsy endpoint evaluation; 9 of 39 (23%) subjects in the beta-carotene group versus 14 of 30 (47%) in the placebo group had regression of CIN (P = 0.039). Independent risk factors for persistent CIN at 9 months included type-specific persistent HPV infection (OR = 11.38, P = 0.006) and continual HPV infection with a high viral load (OR = 14.25, P = 0.007) at baseline and 9 months, an initial diagnosis of > or =CIN II (OR = 6.74, P = 0.016), and older age (OR for > or =25 years = 4.10, P = 0.072). After controlling for these factors, the beta-carotene and placebo groups did not differ in risk for having CIN at 9 months (OR = 1.53, P = 0.550). Resolution of baseline HPV infection was significantly correlated with non-high-risk HPV types (RR = 2.94, P = 0.015), age <25 years (RR = 2.62, ...Continue Reading

References

Aug 19, 1991·International Journal of Cancer. Journal International Du Cancer·E A MorrisonR D Burk
Mar 1, 1990·European Journal of Epidemiology·V KatajaJ T Salonen
Jun 15, 1989·International Journal of Cancer. Journal International Du Cancer·R VerreaultK Shy
Oct 1, 1989·American Journal of Obstetrics and Gynecology·P R PalanJ Basu
Jun 1, 1988·Gynecologic Oncology·C La VecchiaE Negri
May 1, 1986·Obstetrics and Gynecology·K NasiellM Nasiell
Sep 20, 1995·Journal of the National Cancer Institute·G Y HoS Romney
Aug 1, 1994·The Journal of Infectious Diseases·A W HsingM Manos
May 2, 1996·The New England Journal of Medicine·G S OmennS Hammar
Jan 1, 1996·Cancer Causes & Control : CCC·N Potischman, L A Brinton

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Citations

Dec 31, 2002·BJOG : an International Journal of Obstetrics and Gynaecology·Ciaran B J Woodman, Stuart Collins
Feb 12, 1998·The New England Journal of Medicine·G Y HoR D Burk
Aug 13, 2008·The Journal of Infectious Diseases·Laura K SycuroLaura A Koutsky
Sep 6, 2001·Journal of the National Cancer Institute·M FollenD Schottenfeld
Jul 20, 2006·Journal of the National Cancer Institute·Anna A DaviesSteven Thomas
Aug 4, 2011·Journal of Lower Genital Tract Disease·Gloria Y F HoUNKNOWN Albert Einstein Cervix Dysplasia Clinical Consortium
Jan 27, 2005·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·M C Bell, R D Alvarez
Apr 25, 2012·Annual Review of Nutrition·Susan T MayneBrenda Cartmel
Jan 3, 2006·Best Practice & Research. Clinical Obstetrics & Gynaecology·Peter Sasieni
Oct 27, 2001·Journal of the American Dietetic Association·C L RockM T Ruffin
Aug 4, 2004·Journal of Pediatric and Adolescent Gynecology·Tina SimpsonM Kim Oh
Oct 10, 1998·International Journal of Cancer. Journal International Du Cancer·G Y HoS L Romney
Nov 7, 2003·Cancer·Michele FollenTerri L Cornelison
Oct 20, 2006·Journal of Lower Genital Tract Disease·Michael H SilvermanJeffrey S Weber
Oct 20, 2006·Journal of Lower Genital Tract Disease·Michael T McHaleBradley J Monk
Sep 16, 2003·Sexually Transmitted Diseases·M Kim OhJeanne Merchant
Feb 3, 2004·Obstetrics and Gynecology·Francisco GarciaKathleen J Beach
Jun 8, 2001·Current Oncology Reports·M T Ruffin, C L Rock
May 25, 2005·International Journal of Cancer. Journal International Du Cancer·Reina García-ClosasCarlos A González
Feb 20, 2009·International Journal of Clinical Oncology·Chumnan Kietpeerakool, Jatupol Srisomboon
Mar 16, 2012·The Cochrane Database of Systematic Reviews·Goran BjelakovicChristian Gluud
Apr 5, 2000·Nutrition Reviews·W A PryorC L Rock
Jul 29, 2003·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·P R PalanS L Romney
Nov 10, 1998·International Journal of Cancer. Journal International Du Cancer·G Y HoR D Burk
Mar 3, 1998·Nutrition Reviews·A R Giuliano, S Gapstur
Dec 3, 2004·Cancer Research·Chandrika J PiyathilakeEdward E Partridge
May 4, 2000·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·W B Armstrong, F L Meyskens
Jan 15, 1999·Hematology/oncology Clinics of North America·C L Rock

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