PMID: 7546992Aug 1, 1995Paper

Effects of beta receptor antagonists in patients with clinical evidence of heart failure after myocardial infarction: double blind comparison of metoprolol and xamoterol

British Heart Journal
H PerssonL Erhardt

Abstract

To evaluate whether xamoterol, a partial agonist, would improve exercise time more than metoprolol in patients with mild to moderate heart failure after a myocardial infarction. Single-centre double blind randomised parallel group comparison of metoprolol 50-100 mg and xamoterol 100-200 mg twice daily. 210 patients aged 40-80 years (173 men) with clinical evidence of heart failure early after a myocardial infarction. 106 were given metoprolol and 104 xamoterol. Exercise test results and performance at three months; the exercise test, quality of life, and clinical assessments at baseline (5-7 days after the infarction) and after 3, 6, and 12 months. Exercise time increased at three months by 22% in the metoprolol group and 29% in the xamoterol group, but with no significant difference between the groups. Patients taking xamoterol showed overall non-significantly higher mean values of exercise time achieved with higher heart rates at rest and exercise. Improvements in quality of life, clinical signs of heart failure, and New York Heart Association functional class were seen in both treatment groups over one year, with minor benefits of xamoterol on breathlessness, peripheral oedema, and functional class. Eighteen patients taking ...Continue Reading

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Citations

Sep 5, 2001·International Journal of Cardiology·D J van Veldhuisen, P A Poole-Wilson
Aug 24, 2005·Journal of Interventional Cardiology·Stephen J MattichakCindy L Grines
Apr 17, 2016·British Journal of Clinical Pharmacology·Charles KhouriMatthieu Roustit
Oct 21, 2003·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Luigi AscioneBernardino Tuccillo
May 21, 2003·Acta Psychiatrica Scandinavica. Supplementum·H UrdahlUNKNOWN SOHO Study Group
Jun 18, 2021·Vascular Health and Risk Management·Atul Pathak, Sanaa Mrabeti

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