PMID: 8959529Nov 1, 1996Paper

Effects of bifemelane hydrochloride on atherosclerosis in aged rats fed low-calcium diets

The Journal of International Medical Research
M YasuiA Oshima

Abstract

The preventative effects of bifemelane (4-(o-benzylphenoxy)-N-methylbutylamine hydrochloride) on atherosclerosis in aged rats fed low-calcium diets were investigated. Male 18-month-old Wistar rats were maintained for 90 days on the following: (A) standard diet (n = 7), (B) low calcium, low magnesium, high aluminium diet (n = 8), (C) standard diet plus oral intubation with 10 mg bifemelane/kg daily (n = 6), (D) low calcium and magnesium, high aluminium diet plus oral intubation with 10 mg bifemelane/kg daily (n = 6). All groups were give these diets and water ad lib for 90 days, after which blood samples were taken from the abdominal aorta and samples of aorta were examined for atherosclerotic changes. The serum concentrations of the following were determined: calcium, magnesium, zinc, aluminium, inorganic phosphorus, cholesterol, glutamate-oxaloacetate transaminase, glutamate-pyruvate transaminase, lactate dehydrogenase, cholinesterase, creatine phosphokinase, blood urea nitrogen and N-terminal parathyroid hormone. The only significant differences between the groups in serum chemistry were reduced concentrations of cholinesterase and magnesium in groups B and D, increased aluminium in group B, and increased N-terminal parathyro...Continue Reading

References

Sep 1, 1990·The Journal of International Medical Research·M YasuiA Oshima
Sep 1, 1990·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·Y OuchiH Orimo
Sep 1, 1989·American Journal of Physical Anthropology·R M GarrutoJ Tobin
Feb 20, 1986·The New England Journal of Medicine·R Ross
Nov 1, 1981·Stroke; a Journal of Cerebral Circulation·J AstrupL Symon
Feb 1, 1983·Proceedings of the Society for Experimental Biology and Medicine·A TanimuraH C Anderson
Mar 1, 1994·The Journal of Nutrition·J D Browning, B L O'Dell

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