Effects of bile acids on development of pepsinogen-altered pyloric glands in rats

Cancer Letters
S YamaguchiN Ito

Abstract

The effects of dietary bile acids on the development of pepsinogenaltered pyloric glands (PAPG) were examined. Male WKY/NCrj rats were given a single dose of 160 mg/kg body wt. of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) by gastric intubation and fed basal diet containing 0.3% sodium taurocholate (Na-TC), 0.3% sodium cholate (Na-C), 0.3% sodium glycocholate (Na-GC), 0.3% sodium tauroglycocholate, 0.3% sodium deoxycholate, 0.1% chenodeoxycholic acid or 0.5% lithocholic acid for 14 weeks. All rats also received 1 ml of saturated NaCl solution 4 times by i.g. intubation. At the end of week 16, the animals were killed, and the number of PAPG per cm of mucosal length was determined immunohistochemically. Na-TC, Na-C and Na-GC significantly increased the number of PAPG over the control value, suggesting that they may have activity to promote gastric carcinogenesis.

References

Feb 1, 1979·Journal of Clinical Pathology·A Savage, S Jones
Nov 27, 1971·Lancet·H Stalsberg, S Taksdal
May 26, 1972·Biochemical and Biophysical Research Communications·C FurihataT Sugimura
Apr 1, 1966·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·R C Graham, M J Karnovsky
Mar 1, 1980·European Journal of Biochemistry·C FurihataT Sugimura

Citations

Jan 1, 1992·Teratogenesis, Carcinogenesis, and Mutagenesis·Y YoshidaN Ito
Oct 1, 1992·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Y ShichinoN Ito

Related Concepts

Metazoa
Bile Salts
Structure of Pyloric Gland
Immunocytochemistry
Methylnitronitrosoguanidine
Pepsinogen B
Pyloric Sphincter Structure
August Rats
Stomach
Hereditary Diffuse Gastric Cancer

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