Effects of "binge" pattern cocaine on stereotypy and locomotor activity in C57BL/6J and 129/J mice

Pharmacology, Biochemistry, and Behavior
S D SchlussmanM J Kreek

Abstract

This study characterized the behavioral response to cocaine in two strains of mice, the C57BL/6J and 129/J strains, commonly utilized as host strains for transgenic and "knockout" mice. The psychomotor stimulating effects of four doses of cocaine (2.5, 5.0, 10.0, and 15.0 mg/kg/injection) with a saline control, administered in a "binge" pattern (three equal injections at hourly intervals) for 3 days were examined in adult male C57BL/6J and 129/J mice. Behavioral stereotypy in the home cage, was rated 15, 30, and 45 min following each injection. Spontaneous locomotor activity in the home cage was also monitored. Cocaine, at doses of 10.0 or 15.0 mg/kg, produced behavioral stereotypy in both C57BL/6J mice (p < 0.0001) and 129/J mice (p < 0.0001), whereas lower doses did not. The magnitude of stereotypy was significantly lower in 129/J mice than in C57BL/6J mice receiving identical doses of cocaine. C57BL/6J mice also demonstrated a dose-dependent cocaine-induced stimulation of locomotor activity following administration of 10.0 or 15.0 mg/kg of cocaine (p < 0.0005). In contrast, 129/J mice did not exhibit increased locomotion in response to any dose of cocaine tested. These results demonstrate that strain differences in drug-indu...Continue Reading

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Citations

Sep 15, 2012·Psychopharmacology·Amanda E D Van SwearingenCynthia M Kuhn
Aug 2, 2002·Pharmacology, Biochemistry, and Behavior·Yong ZhangMary Jeanne Kreek
May 22, 2003·Pharmacology, Biochemistry, and Behavior·Stefan D SchlussmanMary Jeanne Kreek
Feb 23, 2000·Pharmacology, Biochemistry, and Behavior·A Kuzmin, B Johansson
Mar 29, 2003·Brain Research. Brain Research Reviews·Joanna M KarasinskaBrian F O'Dowd
Mar 21, 2001·Behavioral Neuroscience·K M Frick, J Berger-Sweeney
Jun 7, 2013·PloS One·Eirik SøvikAndrew B Barron
Jun 27, 2008·Neuroscience Letters·Stefan D SchlussmanMary Jeanne Kreek
Feb 24, 2007·Physiology & Behavior·Emily H Geary, Chana K Akins
Sep 29, 2004·Neurotoxicology and Teratology·Lois E McCarthyMichelle E Ehrlich
Aug 3, 2011·Behavioral and Brain Functions : BBF·Amy F Eisener-DormanLisa M Tarantino
Nov 28, 2006·Behavioural Brain Research·Najet Serradj, Marc Jamon
Oct 8, 2013·Neuroscience Letters·Krishna E Tobón, Eldo V Kuzhikandathil
Dec 18, 2010·Pharmacology, Biochemistry, and Behavior·Renee L Good, Richard A Radcliffe
Mar 20, 2003·Psychopharmacology·Chris DowningBruce C Dudek
Dec 24, 2002·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Rebecca J Ralph-WilliamsMark A Geyer
Jul 15, 2021·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Li HeJennifer L Whistler

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