Effects of bioenergetics, temperature and cadmium on liver mitochondria reactive oxygen species production and consumption

Aquatic Toxicology
Chidozie N OkoyeCollins Kamunde

Abstract

A by-product of mitochondrial substrate oxidation and electron transfer to generate cellular energy (ATP) is reactive oxygen species (ROS). Superoxide anion radical and hydrogen peroxide (H2O2) are the proximal ROS produced by the mitochondria. Because low levels of ROS serve critical regulatory roles in cell physiology while excessive levels or inappropriately localized ROS result in aberrant physiological states, mitochondrial ROS need to be tightly regulated. While it is known that regulation of mitochondrial ROS involves balancing the rates of production and removal, the effects of stressors on these processes remain largely unknown. To illuminate how stressors modulate mitochondrial ROS homeostasis, we investigated the effects of temperature and cadmium (Cd) on H2O2 emission and consumption in rainbow trout liver mitochondria. We show that H2O2 emission rates increase with temperature and Cd exposure. Energizing mitochondria with malate-glutamate or succinate increased the rate of H2O2 emission; however, Cd exposure imposed different patterns of H2O2 emission depending on the concentration and substrate. Specifically, mitochondria respiring on malate-glutamate exhibited a saturable graded concentration-response curve that ...Continue Reading

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Citations

Sep 30, 2020·Environmental Science and Pollution Research International·Aiguo DongAiling Dong
Jun 4, 2020·Environmental Science and Pollution Research International·Shirin MoradkhaniAmir Nili-Ahmadabadi
Jan 1, 2021·Free Radical Biology & Medicine·Chidozie N OkoyeCollins Kamunde
Dec 12, 2019·Free Radical Biology & Medicine·Michael O Isei, Collins Kamunde
Oct 29, 2020·The Journal of Experimental Biology·Dillon J Chung, Patricia M Schulte
Dec 18, 2020·Frontiers in Cell and Developmental Biology·Jacopo Junio Valerio BrancaMatteo Becatti
Sep 28, 2021·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Daniel J Ritchie, Christopher R Friesen
Nov 4, 2021·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Chidozie N OkoyeCollins Kamunde

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