Effects of bipolar point and line stimulation in anisotropic rabbit epicardium: assessment of the critical radius of curvature for longitudinal block

IEEE Transactions on Bio-medical Engineering
S B Knisley, B C Hill

Abstract

Excitation front shape and velocity were studied in anisotropic perfused rabbit epicardium stained with potentiometric fluorescent dye. In the combined results from all experiments, convex excitation fronts produced by stimulation with a single electrode propagated longitudinally 13.3% slower than flat excitation fronts produced by stimulation with a line of electrodes. For transverse propagation, the two stimulation methods produced similar flat excitation fronts and velocities. The critical excitation front radius of curvature for longitudinal block (Rcr), calculated from excitable media theory, was 92 microns in control hearts. In hearts exposed to diacetyl monoxime (20 mmol/L), which decreases inward sodium current, Rcr was 175 microns. The slower longitudinal propagation velocity of convex fronts versus flat fronts and the theoretically predicted critical radius of curvature may be important for propagation and block of ectopic depolarizations in the heart.

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Citations

Apr 16, 1998·Journal of Electrocardiology·S B Knisley
Oct 24, 1998·Progress in Biophysics and Molecular Biology·F J Vetter, A D McCulloch
Oct 24, 1998·Progress in Biophysics and Molecular Biology·A T Winfree
Nov 26, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Martin J BishopPeter Kohl
May 4, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Veniamin Y SidorovJohn P Wikswo
Jan 15, 2000·Journal of Cardiovascular Electrophysiology·J JalifeD Vaidya
Dec 24, 1997·Cardiology Clinics·C Cabo, A L Wit
Feb 1, 2008·IEEE Transactions on Bio-medical Engineering·Rashida A AbbasJohn P Wikswo
Mar 11, 2009·IEEE Transactions on Bio-medical Engineering·Elliot B BourgeoisJack M Rogers
Apr 23, 2011·IEEE Transactions on Bio-medical Engineering·Huda AsfourMatthew W Kay
Aug 16, 2000·IEEE Transactions on Bio-medical Engineering·S B Knisley
Jan 18, 2005·IEEE Transactions on Bio-medical Engineering·Matthew W Kay, Richard A Gray
Dec 7, 2005·Progress in Biophysics and Molecular Biology·Emilia Entcheva, Harold Bien
Jan 28, 2015·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Francesco ZanonFrits W Prinzen
Aug 31, 1999·Biophysical Journal·S B KnisleyF Aguel
Mar 27, 2004·Physiological Reviews·André G Kléber, Yoram Rudy
Apr 24, 2002·Physical Review. E, Statistical Physics, Plasmas, Fluids, and Related Interdisciplinary Topics·P Comtois, A Vinet
Jun 19, 2012·American Journal of Physiology. Heart and Circulatory Physiology·Yoshio TakemotoKaichiro Kamiya
Aug 13, 1999·The American Journal of Physiology·N BursacL E Freed
Jan 14, 2021·Arrhythmia & Electrophysiology Review·Irum KotadiaMatthew Wright
May 1, 2021·International Journal of Molecular Sciences·Antonio Rodríguez-SinovasIgnacio Ferreira-González

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