Effects of birth weight and dietary fat on intake, body composition, and plasma thyroxine in neonatal lambs.

Journal of Animal Science
Jose M Ramos-NievesYves R Boisclair

Abstract

Intrauterine growth restriction (IUGR) is often observed in one of the fetuses carried by well-fed prolific ewes. This condition is the result of an insufficient placental size to cover the nutritional needs of the fetus during the near exponential growth phase of the last trimester. After birth, these IUGR offspring have an elevated appetite and lower maintenance energy requirements, suggesting dysregulation of homeostatic systems governing energy metabolism. It is also unknown whether the consequent increase in fatness occurs similarly in both visceral and carcass fractions. To address these questions, lambs differing in birth size (BS, IUGR vs. Normal, 2.6 ± 0.05 vs. 4.2 ± 0.07 kg, P < 0.001) were offered unlimited amounts of a low fat [LF; 22% of dry matter (DM)] or a high fat (HF; 38% of DM) milk replacer and slaughtered on day 14 of postnatal age (n = 7 to 8 for each BS × Diet); a second group of IUGR lambs (n = 3 for each diet) was slaughtered when they reached 8.5 kg, corresponding to the weight of Normal lambs on day 14. When normalized to body weight (BW), the DM and energy intake of IUGR lambs were higher than those of Normal lambs over the first 14 d of life (BS, P < 0.01), but contrary to expectations, the HF diet ...Continue Reading

References

Oct 1, 1978·Analytical Biochemistry·A Hara, N S Radin
Aug 1, 1973·Journal of Animal Science·P W Chiou, R M Jordan
Jan 1, 1996·Reproduction, Fertility, and Development·S J SchermerM E Symonds
Jul 14, 2000·American Journal of Physiology. Endocrinology and Metabolism·M H VickersP D Gluckman
Jun 10, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·M H VickersP D Gluckman
Dec 4, 2003·The Journal of Nutrition·Richard A EhrhardtYves R Boisclair
May 7, 2004·Reproduction : the Official Journal of the Society for the Study of Fertility·S T ButlerW R Butler
Dec 3, 2005·The Journal of Clinical Investigation·Michael RosenbaumRudolph L Leibel
Oct 7, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Miles J De BlasioJulie A Owens
Dec 13, 2006·American Journal of Human Biology : the Official Journal of the Human Biology Council·Peter D GluckmanAlan S Beedle
Jun 15, 2007·The Journal of Pharmacology and Experimental Therapeutics·April D StraderOfer Reizes
Jan 26, 2011·The Journal of Physiology·Nathan M LongPeter W Nathanielsz
Jul 5, 2012·American Journal of Physiology. Endocrinology and Metabolism·Weiyi ChenPablo J Enriori
Apr 3, 2014·Physiological Reviews·Rashmi MullurGregory A Brent
Jul 27, 2014·The Journal of Endocrinology·Michael Rosenbaum, Rudolph L Leibel
Mar 10, 2016·The Journal of Endocrinology·Richard A EhrhardtYves R Boisclair
Aug 28, 2019·Diabetologia·Denise S Fernandez-TwinnRichard Saffery
Oct 2, 2019·The Journal of Clinical Investigation·Lavanya Vishvanath, Rana K Gupta
Jun 20, 2020·The Lancet. Diabetes & Endocrinology·Norbert Stefan

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