Effects of bisaramil on coronary-occlusion-reperfusion injury and free-radical-induced reactions

Pharmacological Research : the Official Journal of the Italian Pharmacological Society
M ParóczaiE Kárpáti

Abstract

The aim of this study was to determine whether bisaramil-an antiarrhythmic compound under clinical investigation-influences the reperfusion-induced arrhythmias and biochemical parameters characterizing occlusion-reperfusion-induced free-radical reactions. The left descending coronary artery (LAD) was occluded for 60 min in anaesthetized dogs followed by one hour of reperfusion. Blood samples were taken at different times of the occlusion and reperfusion for the determination of plasma concentration of malondialdehyde (MDA), reduced (GSH) and oxidized glutathione (GSSG); furthermore of the activity of catalase and superoxide dismutase (SOD). Free-radical generating capacity of polymorph neutrophil granulocytes (PMN) was also measured. At the end of the experiments heart tissue samples were excised from the injured areas and from the intact part of the left ventricular muscle. In tissues samples the concentrations of MDA and GSH and the activity of SOD were determined. Bisaramil was given as an i.v. bolus injection at a dose of 2 mg kg-1 several minutes prior to the end of LAD-occlusion; then the administration was repeated in the 30th minute of reperfusion. In the control group (10 dogs) ventricular fibrillation (VF) occurred in...Continue Reading

Citations

Apr 1, 1997·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·M ParóczaiE Kárpáti
Dec 31, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·M K PugsleyM J A Walker

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