Effects of bisoprolol in patients with stable congestive heart failure

Annales de cardiologie et d'angéiologie
P de GrooteC Bauters

Abstract

To analyze the effect of bisoprolol in patients with stable congestive heart failure and who tolerated beta-blockers. Two hundred and one patients performed before and 3 months after maximal tolerated doses of bisoprolol have been reached, a clinical evaluation, an echocardiography, a radionuclide angiography, a cardiopulmonary exercise test and hormonal determinations. Mean dose of bisoprolol was 8.8 +/- 2.4 mg/d. Patients had a significant improvement in NYHA classification. Heart rate at rest decreased from 87 +/- 17 to 66 +/- 12 beats/min (P < 0.0001) without any effect on electrocardiographic parameters. Left ventricular ejection fraction improved from 31 +/- 11 to 41 +/- 13% (P < 0.0001), with a significant decrease in end-diastolic and end-systolic left ventricle diameters and volumes. Mitral profile improved. Peak VO2 increased from 16.1 +/- 5 to 16.8 +/- 5.5 ml/min/kg (P = 0.001) with a significant increase in O2 pulse (from 8.52 +/- 2.7 to 11.2 +/- 3.5 ml/min/beats, P < 0.0001). Plasma levels of A-type and of B-type natriuretic peptides and of norepinephrine significantly decreased after bisoprolol. Bisoprolol significantly improved left ventricle ejection fraction with a reverse remodeling of the left ventricle, a de...Continue Reading

References

Mar 15, 1996·The American Journal of Cardiology·F PoussetJ Y Le Heuzey
Jun 2, 2001·The New England Journal of Medicine·M PackerUNKNOWN Carvedilol Prospective Randomized Cumulative Survival Study Group

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Citations

Dec 3, 2009·The Journal of Toxicological Sciences·Hirofumi MinomoRyoichi Nagata
Dec 21, 2007·Micron : the International Research and Review Journal for Microscopy·Andrei B BorisovMark W Russell
Apr 25, 2007·Chronobiology International·Ilaria ColognesiMirko Pinotti
Sep 30, 2020·The Egyptian Heart Journal : (EHJ) : Official Bulletin of the Egyptian Society of Cardiology·Yasser Gaber MetwallyInass Fahiem Shaltout

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