Effects of bisphenol A treatment during pregnancy on kidney development in mice: a stereological and histopathological study

Journal of Developmental Origins of Health and Disease
P NuñezJ Arguelles

Abstract

Bisphenol A (BPA) is a chemical found in plastics that resembles oestrogen in organisms. Developmental exposure to endocrine-disrupting chemicals, such as BPA, increases the susceptibility to type 2 diabetes (T2DM) and cardiovascular diseases. Animal studies have reported a nephron deficit in offspring exposed to maternal diabetes. The aim of this study was to investigate the prenatal BPA exposure effects on nephrogenesis in a mouse model that was predisposed to T2DM. This study quantitatively evaluated the renal structural changes using stereology and histomorphometry methods. The OF1 pregnant mice were treated with a vehicle or BPA (10 or 100 μg/kg/day) during days 9-16 of gestation (early nephrogenesis). The 30-day-old offspring were sacrificed, and tissue samples were collected and prepared for histopathological and stereology studies. Glomerular abnormalities and reduced glomerular formation were observed in the BPA offspring. The kidneys of the BPA10 and BPA100 female offspring had a significantly lower glomerular number and density than those of the CONTROL female offspring. The glomerular histomorphometry revealed a significant difference between the female and male CONTROL offspring for the analysed glomerular paramete...Continue Reading

References

Feb 1, 1992·The Anatomical Record·J R Nyengaard, T F Bendtsen
Jan 1, 1995·International Review of Cytology·J F Bertram
Jan 10, 2003·The New England Journal of Medicine·Gunhild KellerKerstin Amann
Jan 24, 2003·International Journal of Epidemiology·D J P BarkerC Osmond
Feb 22, 2003·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Karen M MoritzE Marelyn Wintour
Jul 17, 2003·Kidney International. Supplement·Kevin V Lemley
May 6, 2005·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Yashpal S KanwarFarhad R Danesh
Jul 29, 2005·Hypertension·Sarah McMullen, Simon C Langley-Evans
Jan 18, 2006·Hypertension·Kambiz Zandi-NejadBarry M Brenner
Feb 29, 2008·Journal of the American Society of Nephrology : JASN·Stella TranShao-Ling Zhang
Apr 22, 2008·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Hui-Mei ChenZhi-Hong Liu
Feb 6, 2010·Medical Principles and Practice : International Journal of the Kuwait University, Health Science Centre·Simon C Langley-Evans, Sarah McMullen
Apr 28, 2010·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Yun-Wen ChenShao-Ling Zhang
May 12, 2010·Nature Biotechnology·Joseph V BonventreFrank Dieterle
May 22, 2010·Environmental Health Perspectives·Paloma Alonso-MagdalenaAngel Nadal
Oct 22, 2010·American Journal of Physiology. Renal Physiology·Yun-Wen ChenShao-Ling Zhang
Nov 3, 2010·Environmental Science & Technology·Arnold SchecterLinda Birnbaum
Mar 18, 2011·American Journal of Physiology. Renal Physiology·Scott C BeemanKevin M Bennett
Apr 7, 2011·Nature Reviews. Endocrinology·Paloma Alonso-MagdalenaAngel Nadal
Sep 9, 2011·The Journal of Steroid Biochemistry and Molecular Biology·Thaddeus T SchugJerrold J Heindel
Jun 1, 2012·Toxicologic Pathology·Kendall S FrazierAxel Bube
Sep 13, 2012·Toxicologic Pathology·Sherry J MorganLaura Conour
Feb 19, 2014·Nephrology·Debra FongReetu R Singh
Apr 12, 2014·Current Molecular Pharmacology·Sivakumar J T Gowder
Aug 1, 2012·Journal of Developmental Origins of Health and Disease·F R CagampangM A Hanson
Aug 1, 2010·Journal of Developmental Origins of Health and Disease·W E HoyJ F Bertram
Jun 19, 2015·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Go KanzakiTakashi Yokoo
Jun 24, 2015·Nature Reviews. Nephrology·Anglina KatariaHoward Trachtman
Jul 16, 2015·Journal of Developmental Origins of Health and Disease·K L Thornburg
Aug 4, 2015·Journal of Developmental Origins of Health and Disease·P NuñezC Perillan
Aug 5, 2015·Journal of Clinical Medicine·Alberto Martínez-CastelaoFernando de Alvaro
Sep 18, 2015·Journal of Developmental Origins of Health and Disease·S A JohnsonC S Rosenfeld

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Citations

May 16, 2019·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Javad Sadeghinezhad, Jens R Nyengaard
Jul 21, 2020·Oxidative Medicine and Cellular Longevity·Afsaneh NematiMohammadreza Gholami
Aug 27, 2021·Microscopy Research and Technique·Javad Sadeghinezhad, Jens R Nyengaard

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