Effects of blood gas/pH abnormalities on the cardiovascular actions of verapamil in rats

Clinical and Experimental Pharmacology & Physiology
F I Achike, S Dai

Abstract

1. The effects of hypoxaemia, hyperoxaemia, alkalosis, acidosis, hypocarbia with alkalosis or hypercarbia with acidosis on the blood pressure and pulse rate responses to verapamil were studied in chloralose-anaesthetized rats. 2. At a fixed stroke volume (10 mL/kg) and rate (80 strokes/min; except for the hypocarbic group at 160 strokes/min), hypoxaemia, hyperoxaemia, hypercarbia with acidosis, or hypocarbia with alkalosis was induced by artificial ventilation with gas mixtures containing 17% O2, 28% O2, 23% O2, with 5% CO2, or 17% O2, without CO2 respectively. Acidosis or alkalosis was produced by intravenous infusion of 1 mol/L HCl or 1 mol/L NaHCO3 respectively, in animals artificially ventilated with room air. 3. Changes in individual blood gas/pH parameters had no significant effect on blood pressure except for acidosis which caused a significant decrease. Effects on pulse rate were significant increases in the alkalosis and hypercarbia groups, decrease in the acidosis group, while in other conditions no significant changes were recorded. 4. In the controls, intravenous injections of verapamil 20-320 micrograms/kg caused dose-dependent increases in mean blood pressure, while effects on pulse rate were not marked. 5. The hy...Continue Reading

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Citations

May 15, 1996·Environmental Toxicology and Pharmacology·F I AchikeC W Ogle
Apr 1, 1991·Clinical and Experimental Pharmacology & Physiology·F I Achike, S Dai
Sep 17, 2004·American Journal of Human Genetics·Jonathan L Rees
Jul 6, 2007·European Journal of Pain : EJP·Roman RukwiedMartin Schmelz

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