Abstract
To perform a systematic review of the effect of blood glucose levels on 2-Deoxy-2-[18F]fluoro-D-glucose (18F-FDG) uptake in normal organs. We searched the MEDLINE, EMBASE and Cochrane databases through 22 April 2017 to identify all relevant studies using the keywords "PET/CT" (positron emission tomography/computed tomography), "standardized uptake value" (SUV), "glycemia," and "normal." Analysis followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses recommendations. Maximum and mean SUVs and glycemia were the main parameters analyzed. To objectively measure the magnitude of the association between glycemia and 18F-FDG uptake in different organs, we calculated the effect size (ES) and the coefficient of determination (R2) whenever possible. The literature search yielded 225 results, and 14 articles met the inclusion criteria; studies included a total of 2714 (range, 51-557) participants. The brain SUV was related significantly and inversely to glycemia (ES = 1.26; R2 0.16-0.58). Although the liver and mediastinal blood pool were significantly affected by glycemia, the magnitudes of these associations were small (ES = 0.24-0.59, R2 = 0.01-0.08) and negligible (R2 = 0.02), respectively. Lung, bone marrow, ...Continue Reading
References
Jan 1, 1983·Journal of Neurochemistry·P D CraneW H Oldendorf
Dec 1, 1993·Radiology·K R Zasadny, R L Wahl
Nov 25, 2000·Nuclear Medicine and Biology·M M GrahamR M Hayward
Jan 25, 2002·European Journal of Nuclear Medicine and Molecular Imaging·H W YeungY E Erdi
Mar 18, 2003·European Journal of Nuclear Medicine and Molecular Imaging·Nanda C KrakAdriaan A Lammertsma
Dec 18, 2004·European Journal of Nuclear Medicine and Molecular Imaging·Michel de GrootWim J G Oyen
May 24, 2006·Annals of Nuclear Medicine·Tomohiro KanetaShogo Yamada
May 2, 2007·International Journal of Epidemiology·Simon SandersonJulian P T Higgins
May 24, 2008·Annals of Nuclear Medicine·Keiichi KawasakiKiichi Ishiwata
Jun 24, 2009·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Richard L WahlMartin A Lodge
Jun 19, 2009·Primary Care Diabetes·Aristofanis GikasStavros Pappas
Oct 20, 2009·European Journal of Nuclear Medicine and Molecular Imaging·Andrea VarroneUNKNOWN European Association of Nuclear Medicine Neuroimaging Committee
Feb 23, 2010·International Journal of Surgery·David MoherUNKNOWN PRISMA Group
Mar 20, 2010·Annals of Nuclear Medicine·Jonas ClaeysIngeborg Goethals
Jul 24, 2010·AJR. American Journal of Roentgenology·Michael C AdamsTerence Z Wong
Apr 16, 2011·Nuclear Medicine and Biology·Kazuo KubotaHitoshi Shibuya
Dec 12, 2012·Nuclear Medicine and Biology·Karen A BüsingKlaus Wasser
Mar 21, 2013·Clinical Nuclear Medicine·David GroheuxElif Hindié
Apr 5, 2013·Journal of Medical Imaging and Radiation Oncology·Ashish MalladiRathan M Subramaniam
Jan 1, 2012·Indian Journal of Nuclear Medicine : IJNM : the Official Journal of the Society of Nuclear Medicine, India·Manohar KuruvaAnish Bhattacharya
Jul 9, 2013·EJNMMI Research·Henry LindholmHans Jacobsson
Dec 3, 2014·European Journal of Nuclear Medicine and Molecular Imaging·Ronald BoellaardUNKNOWN European Association of Nuclear Medicine (EANM)
Jan 17, 2015·Journal of Evidence-based Medicine·Xiantao ZengLiang Du
Feb 26, 2015·Nuclear Medicine Communications·Asae NozawaCarl K Hoh
Apr 19, 2015·Nuclear Medicine Communications·Ryan L WebbArnold Brenner
Apr 23, 2015·European Radiology·Georgia KeramidaA Michael Peters
Feb 15, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Benjamin L VigliantiMilton D Gross
Citations
Aug 31, 2018·Interactive Cardiovascular and Thoracic Surgery·Tao LuQun Wang
Sep 8, 2020·European Journal of Nuclear Medicine and Molecular Imaging·André H DiasLars C Gormsen
Nov 9, 2018·Medicine·Rang WangChengzhong Fan
Jan 18, 2019·Annals of Nuclear Medicine·Christopher SilmanKenichiro Otsuka
Jul 11, 2020·Acta Diabetologica·Qingqing ZhaoYifan Zhang
Oct 6, 2020·Frontiers in Oncology·Chunsheng WangYipeng Song
Dec 20, 2018·Molecular Brain·Young-Suk ChoiJong Eun Lee
Apr 29, 2020·Alzheimer's Research & Therapy·Peter N E YoungMichael Schöll
Feb 27, 2019·European Journal of Nuclear Medicine and Molecular Imaging·Stephan AltmayerBruno Hochhegger
Dec 25, 2019·EJNMMI Research·Janusch BlautzikThomas Pfluger
Jul 24, 2020·Cancers·Dongwoo KimMijin Yun
Aug 23, 2020·Brain Sciences·Alexandra C FietsamThorsten Rudroff
Aug 14, 2019·Annals of Nuclear Medicine·Shozo OkamotoMasayuki Inubushi
Dec 19, 2019·Frontiers in Neurology·Chenxing Eleana ZhangHans Vink
Oct 13, 2020·Diabetologia·Kimberly M AlongeMichael W Schwartz
Nov 8, 2020·EJNMMI Research·Christian T McHughRosa T Branca
Jan 6, 2021·European Journal of Radiology·Kentaro FukunagaYasutaka Nakano
Jan 21, 2021·Animals : an Open Access Journal From MDPI·Marieke A StammesFrank A W Verreck
Mar 7, 2021·Cancers·Kenji Hirata, Nagara Tamaki
Feb 19, 2021·IScience·Hanne-Line RabbenChun-Mei Zhao
May 22, 2021·Andrology·Antoni BochińskiTet Yap
May 30, 2021·Seminars in Nuclear Medicine·Esra Arslan, Tevfik Fikret Çermik