Effects of blood pressure lowering and metabolic control on systolic left ventricular function in Type II diabetes mellitus

Clinical Science
Niels H AndersenCarl E Mogensen

Abstract

Decreased left ventricular long-axis function may be the earliest stage in subclinical heart failure in Type II diabetes. To assess whether a decrease in SBP (systolic blood pressure) or a change in metabolic control would improve the long-axis function, 48 Type II diabetic patients participating in the CALM II (Candesartan and Lisinopril Microalbuminuria II) study were included in the present study. Patients were examined with tissue Doppler echocardiography at baseline and after 3 and 12 months of follow-up. Corresponding blood pressure, fructosamine and HbA(1c) (glycated haemoglobin) values were obtained. During the follow-up period, a decrease in SBP of 8 mmHg was seen (from 141+/-11 mmHg at baseline to 133+/-12 mmHg; P<0.001) and the peak systolic strain rate was significantly improved (from -1.10+/-0.25 at baseline to -1.25+/-0.22; P<0.01). There was a highly significant relationship between the changes in systolic strain rate, HbA(1c) (P<0.001) and fructosamine (P<0.05), and similarly to changes in left ventricular mass (P<0.05), whereas the correlation to the SBP reduction was not significant. Patients with improved glycaemic control, defined as a reduced HbA(1c) value after 12 months of follow-up, had a significantly i...Continue Reading

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Citations

Oct 15, 2010·Journal of Human Hypertension·Q Shang, G W-K Yip
Apr 25, 2007·Scandinavian Cardiovascular Journal : SCJ·Niels Holmark AndersenJens Sandahl Christiansen
Dec 20, 2011·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Köksal CeyhanOrhan Onalan
Oct 16, 2007·Ultrasound in Medicine & Biology·Niels Holmark AndersenClaus Højbjerg Gravholt
Dec 23, 2006·Progress in Cardiovascular Diseases·Thomas H Marwick, Chiew Y Wong
Dec 22, 2007·Expert Review of Cardiovascular Therapy·Jithendra B SomaratneRobert N Doughty
Apr 15, 2009·Clinical Science·Omar AsgharRayaz A Malik
Oct 18, 2007·Current Opinion in Endocrinology, Diabetes, and Obesity

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